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28-09-2024 | Menopausal Hormone Therapy | Review

Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause

Authors: Koray Gorkem Sacinti, Rowaida Sadat, Sinan Ozkavukcu, Meltem Sonmezer, Murat Sonmezer

Published in: Archives of Gynecology and Obstetrics | Issue 5/2024

Abstract

Ovarian tissue cryopreservation and transplantation (OTCT) offers hope for preserving fertility and endocrine functions in patients undergoing gonadotoxic treatments. Advancements in techniques for the procedure have transformed OTCT from an experimental procedure into a viable option. There is a growing interest in utilizing OTCT to delay menopause and alleviate associated health issues. Menopausal transition affects women globally, leading to symptoms and long- term health risks. OTCT has the potential to restore endocrine functions, reducing menopause-related symptoms while mitigating health consequences such as osteoporosis and cardiovascular diseases. Although the use of OTCT for delaying menopause is not clinically proven, the discussion around shows potential for future utilization. In essence, the remarkable advancements in OTCT have bestowed upon us the ability to safeguard fertility and sustain the delicate endocrine functions of the ovaries. However, it is the tantalizing prospect of utilizing this technique to postpone menopause and alleviate its associated symptoms that truly captivates the imagination. Further research is imperative to substantiate the clinical efficacy of OTCT; nonetheless, its potential in menopausal therapy is both promising and warrants comprehensive exploration. This review highlights advancements and the feasibility of OTCT to postpone menopause as an alternative approach to currently used conventional menopause therapy methods.

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Title: Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause
Authors: Koray Gorkem Sacinti
Rowaida Sadat
Sinan Ozkavukcu
Meltem Sonmezer
Murat Sonmezer
Publication date: 28-09-2024
Publisher: Springer Berlin Heidelberg
Keywords: Menopausal Hormone Therapy
Fertility
Menopause
Hormone Replacement Therapy
Published in: Archives of Gynecology and Obstetrics / Issue 5/2024
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-024-07752-3

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