Potential benefits of hormone replacement therapy on cardiovascular and kidney outcomes in postmenopausal women with chronic kidney disease
- 16-10-2024
- Menopausal Hormone Therapy
- Original Article
Published in:
- Authors
- Semin Cho
- Minsang Kim
- Sehyun Jung
- Jeong Min Cho
- Seong Geun Kim
- Sehoon Park
- Soojin Lee
- Eunjeong Kang
- Yaerim Kim
- Kwon Wook Joo
- Kyungdo Han
- Dong Ki Kim
- Hyuk Huh
- Published in
- Journal of Nephrology | Issue 2/2025
Abstract
Background
Hormone replacement therapy (HRT) is recommended for alleviating vasomotor symptoms or preventing bone loss in postmenopausal women. This study aimed to investigate the impact of hormone replacement therapy on major adverse cardiovascular events, kidney failure, and mortality in women with chronic kidney disease (CKD).
Methods
This population-based cohort study analyzed data from the National Cancer Screening Program and the national health examination of South Korea. Data on postmenopausal women were extracted from the 2009 National Cancer Screening Program. Among these postmenopausal women, those with CKD without kidney replacement therapy were selected through a national health examination from 2009 to 2013. The study outcomes were the risks of major adverse cardiovascular events, kidney failure, and all-cause mortality according to hormone replacement therapy.
Results
A total of 768,279 postmenopausal women with CKD were enrolled in this study; of these women, 13.8% (N = 106,052) had a history of hormone replacement therapy. The user and non-user groups differed with respect to baseline characteristics, with the latter being older and having risk factors for cardiovascular disease. After adjustment for confounding factors, the group exposed to hormone replacement therapy showed lower risks of major adverse cardiovascular events, kidney failure, and all-cause mortality.
Conclusions
This study suggests the potential benefits of hormone replacement therapy in postmenopausal women with CKD and highlighted its potential advantages for cardiovascular and kidney outcomes.
Graphical abstract
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- Title
- Potential benefits of hormone replacement therapy on cardiovascular and kidney outcomes in postmenopausal women with chronic kidney disease
- Authors
-
Semin Cho
Minsang Kim
Sehyun Jung
Jeong Min Cho
Seong Geun Kim
Sehoon Park
Soojin Lee
Eunjeong Kang
Yaerim Kim
Kwon Wook Joo
Kyungdo Han
Dong Ki Kim
Hyuk Huh
- Publication date
- 16-10-2024
- Publisher
- Springer International Publishing
- Keywords
-
Menopausal Hormone Therapy
Chronic Kidney Disease
Estrogens
Hormone Replacement Therapy
Postmenopause
Menopause - Published in
-
Journal of Nephrology / Issue 2/2025
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059 - DOI
- https://doi.org/10.1007/s40620-024-02099-z
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