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16-05-2024 | Melanoma | RESEARCH ARTICLE

Access to melanoma drugs in Spain: a cross-sectional survey

Authors: Maria Gonzalez-Cao, Teresa Puertolas, Jose Luis Manzano, Cayetana Maldonado, Oriol Yelamos, Miguel Ángel Berciano-Guerrero, Pablo Cerezuela, Juan Martin-Liberal, Eva Muñoz-Couselo, Enrique Espinosa, Ana Drozdowskyj, Alfonso Berrocal, Ainara Soria, Ivan Marquez-Rodas, Salvador Martin-Algarra, Maria Quindos, Susana Puig, for the Spanish Melanoma Group (GEM)

Published in: Clinical and Translational Oncology | Issue 10/2024

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Abstract

Background

The development of highly active drugs has improved the survival of melanoma patients, but elevated drug prices place a significant burden on health care systems. In Spain, the public health care system is transferred to the 17 autonomous communities (AACC). The objective of this study is to describe the situation of drug access for melanoma patients in Spain and how this decentralized system is affecting equity.

Methods

From July to September 2023, a cross-sectional survey was sent to members of the Spanish Multidisciplinary Melanoma Group (GEM Group). The questionnaire consulted about the real access to new drugs in each hospital. The responses were collected anonymously and analyzed according to several variables, including the AACC.

Results

The survey was answered by 50 physicians in 15 AACC. No major differences on access between AACC were observed for indications that are reimbursed by the Spanish Health Care System (adjuvant immunotherapy for stage IIIC–IIID and resected stage IV melanoma). Important differences in drug access were observed among AACC and among centers within the same AACC, for most of the EMA indications that are not reimbursed (adjuvant immunotherapy for stages IIB–IIC–IIIA–IIIB) or that are not fully reimbursed (ipilimumab plus nivolumab in advanced stage). Homogeneously, access to adjuvant targeted drugs, TIL therapy and T-VEC, is extremely low or non-existing in all AACC.

Conclusions

For most indications that reimbursement is restricted out of the EMA indication, a great diversity on access was found throughout the different hospitals in Spain, including heterogeneity intra-AACC.
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Literature
6.
go back to reference EFPIA. European Federation of Pharmaceutical Industries and Associations (EFPIA). EFPIA patients W.A.I.T. Indicator 2022 Survey; 2022. EFPIA. European Federation of Pharmaceutical Industries and Associations (EFPIA). EFPIA patients W.A.I.T. Indicator 2022 Survey; 2022.
12.
14.
go back to reference Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V, et al. Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial. The Lancet. 2022;399(10336):1718–29. https://doi.org/10.1016/S0140-6736(22)00562-1.CrossRef Luke JJ, Rutkowski P, Queirolo P, Del Vecchio M, Mackiewicz J, Chiarion-Sileni V, et al. Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial. The Lancet. 2022;399(10336):1718–29. https://​doi.​org/​10.​1016/​S0140-6736(22)00562-1.CrossRef
Metadata
Title
Access to melanoma drugs in Spain: a cross-sectional survey
Authors
Maria Gonzalez-Cao
Teresa Puertolas
Jose Luis Manzano
Cayetana Maldonado
Oriol Yelamos
Miguel Ángel Berciano-Guerrero
Pablo Cerezuela
Juan Martin-Liberal
Eva Muñoz-Couselo
Enrique Espinosa
Ana Drozdowskyj
Alfonso Berrocal
Ainara Soria
Ivan Marquez-Rodas
Salvador Martin-Algarra
Maria Quindos
Susana Puig
for the Spanish Melanoma Group (GEM)
Publication date
16-05-2024
Publisher
Springer International Publishing
Keywords
Melanoma
Melanoma
Published in
Clinical and Translational Oncology / Issue 10/2024
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-024-03501-9

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