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09-05-2024

Mechanisms of Behavior Change for Functional Improvements in Cannabis Use Disorder Treatments: Current Science and Future Outlook

Authors: Bryant M. Stone, Brian J. Sherman

Published in: Current Addiction Reports | Issue 4/2024

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Abstract

Purpose of Review

The rising prevalence of cannabis use disorder (CUD) has prompted an urgent need for effective behavioral treatments to reduce the global public health burden. However, the chances of achieving lifetime abstinence or symptom remission remain low. To address this limitation, we delineated the current research on mechanisms of behavior change (MOBC) for functional impairments in CUD treatments, including new developments, preliminary evidence, and theoretical considerations for unstudied MOBCs.

Recent Findings

MOBC studies were sparse, and intervention studies produced modest, inconsistent improvements to functional impairment. Three well-studied MOBCs appear in the literature: a) contingency-incentivized prolonged abstinence, which produced the largest effects; b) motivational enhancement, which is the most popular and disseminated; and c) coping skills, which produced the most consistent effects. Preliminary work supported cannabis use reductions and behavioral economics as MOBCs, and theoretical considerations support the potential of reducing cue-induced cravings and promoting positive constructs to improve functioning.

Summary

MOBCs for functional impairment in CUD treatments is an emerging area of research. Hypotheses are abundant, but direct evidence is sparse; several significant questions remain. Evidence-based preventive measures, harm reduction strategies, and CUD treatments may become more pertinent in the immediate future, so this area of study is crucial to address the public health consequences of CUD.
Footnotes
1
Improvements in functional impairment may also indirectly result in improvements in symptoms surrounding cannabis use, though, the remission of use problems is not necessary for functional improvements in CUD treatments as shown in these recent studies [1113].
 
2
Decreasing cannabis consumption doesn't always translate to the complete remission of symptoms related to its excessive and prolonged use. For individuals who consume cannabis in exceptionally high quantities, a decrease in usage can lead to functional betterment, although it might not result in the remission of their excessive and prolonged use symptom.
 
3
Mechanism studies for CUD treatment are sparse and limited compared to intervention studies and randomized control trials. We reviewed the evidence for MOBCs for functional impairment and their accompanying treatments to provide a more comprehensive literature review. We noted inconsistent evidence when MOBC deviated from their predominant treatment.
 
4
Note that researchers mention self-efficacy frequently as a potential MOBC for functional improvements for CUD. We omitted a discussion of self-efficacy because of very limited studies, poor characterization (i.e., it may be a part of motivational enhancement, a coping skill, or an outcome), and questionable utility as a MOBC. Although a noteworthy consideration for future research, the promise and trajectory of self-efficacy as a MOBC remains limited.
 
5
Rewards refers to positive emotions and pleasurable sensations from behaviors such as feeling happy while eating or excitement after skydiving, mostly associated with dopamine (wanting) and serotonin (liking; [101]).
 
Literature
4.
go back to reference • American Psychiatric Association. Substance-related and addictive disorders. In: Diagnostic and statistical manual of mental disorders (5th ed., text rev.). https://doi.org/10.1176/appi.books.9781585624836.jb16. [This book chapter contains important information on how to define and characterize of CUD within psychiatry Typically, the definitions found in this book chapter are what people describe when referring to CUD.]. • American Psychiatric Association. Substance-related and addictive disorders. In: Diagnostic and statistical manual of mental disorders (5th ed., text rev.). https://​doi.​org/​10.​1176/​appi.​books.​9781585624836.​jb16. [This book chapter contains important information on how to define and characterize of CUD within psychiatry Typically, the definitions found in this book chapter are what people describe when referring to CUD.].
6.
go back to reference •• Boumparis N, Loheide-Niesmann L, Blankers M, Ebert DD, Korf D, Schaub MP, Spijkerman R, Tait RJ, Riper H. Short-and long-term effects of digital prevention and treatment interventions for cannabis use reduction: A systematic review and meta-analysis. Drug Alcohol Depend. 2019;200:82–94. https://doi.org/10.1016/j.drugalcdep.2019.03.016. [This paper is a well-documented, recent systematic review of the literature on digital treatments for CUD. This topic area is likely to become more relevant as telehealth and mobile health become more popular.]CrossRefPubMed •• Boumparis N, Loheide-Niesmann L, Blankers M, Ebert DD, Korf D, Schaub MP, Spijkerman R, Tait RJ, Riper H. Short-and long-term effects of digital prevention and treatment interventions for cannabis use reduction: A systematic review and meta-analysis. Drug Alcohol Depend. 2019;200:82–94. https://​doi.​org/​10.​1016/​j.​drugalcdep.​2019.​03.​016. [This paper is a well-documented, recent systematic review of the literature on digital treatments for CUD. This topic area is likely to become more relevant as telehealth and mobile health become more popular.]CrossRefPubMed
13.
go back to reference • Sherman BJ, Sofis MJ, Borodovsky JT, Gray KM, McRae-Clark AL, Budney AJ. Evaluating cannabis use risk reduction as an alternative clinical outcome for cannabis use disorder. Psychol Addict Behav. 2022;36(5):505. https://doi.org/10.1037/adb0000760. [This study uses data from the ACCENT pharmacotherapy clinical trial to demonstrate that cannabis use risk reduction is sufficient to result in improvements in clinical outcomes without achieving abstinence.]CrossRefPubMed • Sherman BJ, Sofis MJ, Borodovsky JT, Gray KM, McRae-Clark AL, Budney AJ. Evaluating cannabis use risk reduction as an alternative clinical outcome for cannabis use disorder. Psychol Addict Behav. 2022;36(5):505. https://​doi.​org/​10.​1037/​adb0000760. [This study uses data from the ACCENT pharmacotherapy clinical trial to demonstrate that cannabis use risk reduction is sufficient to result in improvements in clinical outcomes without achieving abstinence.]CrossRefPubMed
14.
go back to reference •• Stone BM. & Sherman BJ. Is it time for a cannabis harm reduction approach? Commentary on Sherman et al. (2021) & Borodovsky et al. (2022). Psychology of Addictive Behaviors. In Press. [This commentary reviews two studies using the ACCENT pharmacotherapy clinical trial to demonstrate that abstinence may not be necessary for functional improvements. The authors propose an official definition for cannabis harm reduction, expand on these findings, how they are increasingly relevant, and the future directions for cannabis harm reduction.] •• Stone BM. & Sherman BJ. Is it time for a cannabis harm reduction approach? Commentary on Sherman et al. (2021) & Borodovsky et al. (2022). Psychology of Addictive Behaviors. In Press. [This commentary reviews two studies using the ACCENT pharmacotherapy clinical trial to demonstrate that abstinence may not be necessary for functional improvements. The authors propose an official definition for cannabis harm reduction, expand on these findings, how they are increasingly relevant, and the future directions for cannabis harm reduction.]
35.
go back to reference •• Witkiewitz K, Pfund RA, Tucker JA. Mechanisms of behavior change in substance use disorder with and without formal treatment. Annu Rev Clin Psychol. 2022;18:497–525. https://doi.org/10.1146/annurev-clinpsy-072720-014802. [The authors of this review paper examine the existing studies on the mechanisms of behavior change for CUD. This review is a thorough guide of the evidence over the last several decades and recently.]CrossRefPubMed •• Witkiewitz K, Pfund RA, Tucker JA. Mechanisms of behavior change in substance use disorder with and without formal treatment. Annu Rev Clin Psychol. 2022;18:497–525. https://​doi.​org/​10.​1146/​annurev-clinpsy-072720-014802. [The authors of this review paper examine the existing studies on the mechanisms of behavior change for CUD. This review is a thorough guide of the evidence over the last several decades and recently.]CrossRefPubMed
43.
go back to reference Daigre C, Rodríguez L, Roncero C, Palma-Alvarez RF, Perea-Ortueta M, Sorribes-Puertas M, Martínez-Luna N, Ros-Cucurull E, Ramos-Quiroga JA, Grau-López L. Treatment retention and abstinence of patients with substance use disorders according to addiction severity and psychiatry comorbidity: a six-month follow-up study in an outpatient unit. Addict Behav. 2021;117:106832. https://doi.org/10.1016/j.addbeh.2021.106832.CrossRefPubMed Daigre C, Rodríguez L, Roncero C, Palma-Alvarez RF, Perea-Ortueta M, Sorribes-Puertas M, Martínez-Luna N, Ros-Cucurull E, Ramos-Quiroga JA, Grau-López L. Treatment retention and abstinence of patients with substance use disorders according to addiction severity and psychiatry comorbidity: a six-month follow-up study in an outpatient unit. Addict Behav. 2021;117:106832. https://​doi.​org/​10.​1016/​j.​addbeh.​2021.​106832.CrossRefPubMed
48.
go back to reference •• Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (HHS Publication No. PEP20-07-01-001, NSDUH Series H-55). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration; 2022. https://www.samhsa.gov/data/. [This source contains important information on SUD characteristics and issues within the United States.] •• Substance Abuse and Mental Health Services Administration. Key substance use and mental health indicators in the United States: Results from the 2019 National Survey on Drug Use and Health (HHS Publication No. PEP20-07-01-001, NSDUH Series H-55). Rockville, MD: Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration; 2022. https://​www.​samhsa.​gov/​data/​. [This source contains important information on SUD characteristics and issues within the United States.]
54.
go back to reference •• Miller WR, Rollnick S. Motivational interviewing: Helping people change (applications of motivational interviewing). Guilford press; 2013. [This book is the definitive guide for Motivational Interviewing. It contains the evidence for its effects, examples, and instructions for practice.] •• Miller WR, Rollnick S. Motivational interviewing: Helping people change (applications of motivational interviewing). Guilford press; 2013. [This book is the definitive guide for Motivational Interviewing. It contains the evidence for its effects, examples, and instructions for practice.]
60.
go back to reference Schaub MP, Wenger A, Berg O, Beck T, Stark L, Buehler E, Haug S. A web-based self-help intervention with and without chat counseling to reduce cannabis use in problematic cannabis users: three-arm randomized controlled trial. J Med Internet Res. 2015;17(10):e4860. https://doi.org/10.2196/jmir.4860.CrossRef Schaub MP, Wenger A, Berg O, Beck T, Stark L, Buehler E, Haug S. A web-based self-help intervention with and without chat counseling to reduce cannabis use in problematic cannabis users: three-arm randomized controlled trial. J Med Internet Res. 2015;17(10):e4860. https://​doi.​org/​10.​2196/​jmir.​4860.CrossRef
66.
79.
go back to reference •• Gates PJ, Sabioni P, Copeland J, Le Foll B, Gowing L. Psychosocial interventions for cannabis use disorder. Cochrane Database Syst Rev. 2016(5). DOI: https://doi.org/10.1002/14651858.CD005336.pub4[This meta-analysis provides a thorough analysis of the existing evidence for the existing interventions for CUD. It focuses primarily on coping skills for the cognitive behavioral therapy and shows consistent effects.] •• Gates PJ, Sabioni P, Copeland J, Le Foll B, Gowing L. Psychosocial interventions for cannabis use disorder. Cochrane Database Syst Rev. 2016(5). DOI: https://​doi.​org/​10.​1002/​14651858.​CD005336.​pub4[This meta-analysis provides a thorough analysis of the existing evidence for the existing interventions for CUD. It focuses primarily on coping skills for the cognitive behavioral therapy and shows consistent effects.]
90.
go back to reference Koffel E, Kuhn E, Petsoulis N, Erbes CR, Anders S, Hoffman JE, Ruzek JI, Polusny MA. A randomized controlled pilot study of CBT-I Coach: feasibility, acceptability, and potential impact of a mobile phone application for patients in cognitive behavioral therapy for insomnia. Health Informatics J. 2018;24(1):3–13. https://doi.org/10.1177/1460458216656472.CrossRefPubMed Koffel E, Kuhn E, Petsoulis N, Erbes CR, Anders S, Hoffman JE, Ruzek JI, Polusny MA. A randomized controlled pilot study of CBT-I Coach: feasibility, acceptability, and potential impact of a mobile phone application for patients in cognitive behavioral therapy for insomnia. Health Informatics J. 2018;24(1):3–13. https://​doi.​org/​10.​1177/​1460458216656472​.CrossRefPubMed
93.
go back to reference • National Academies of Sciences, Engineering, and Medicine. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research. https://doi.org/10.17226/24625. [This source dispels misinformation on the dangers of dying from cannabis use.] • National Academies of Sciences, Engineering, and Medicine. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research. https://​doi.​org/​10.​17226/​24625. [This source dispels misinformation on the dangers of dying from cannabis use.]
102.
go back to reference • Stone BM. Positive Psychology for Substance Use Disorders: A Rationale and Call to Action. J Stud Alcohol Drugs. 2022a;83(6):959–61. https://doi.org/10.15288/jsad.22-00259. [This paper articulates a rationale for using positive psychology to treat SUDs and calls on clinicians and researchers to begin to integrate positive psychology concepts and interventions into their treatments and research.]CrossRefPubMed • Stone BM. Positive Psychology for Substance Use Disorders: A Rationale and Call to Action. J Stud Alcohol Drugs. 2022a;83(6):959–61. https://​doi.​org/​10.​15288/​jsad.​22-00259. [This paper articulates a rationale for using positive psychology to treat SUDs and calls on clinicians and researchers to begin to integrate positive psychology concepts and interventions into their treatments and research.]CrossRefPubMed
130.
go back to reference •• Stone BM, Parks AC. Cultivating subjective well-being through positive psychological interventions. Handbook of well-being. DEF Publishers. DOI: nobascholar.com. 2018. https://www.nobascholar.com/chapters/59/download.pdf[This book chapter summarizes the available evidence on PPIs, provides descriptions and examples of PPIs, and suggested future directions. This book chapter is a good resource for people unfamiliar with PPIs.] •• Stone BM, Parks AC. Cultivating subjective well-being through positive psychological interventions. Handbook of well-being. DEF Publishers. DOI: nobascholar.com. 2018. https://​www.​nobascholar.​com/​chapters/​59/​download.​pdf[This book chapter summarizes the available evidence on PPIs, provides descriptions and examples of PPIs, and suggested future directions. This book chapter is a good resource for people unfamiliar with PPIs.]
135.
go back to reference Seligman ME. Flourish: A visionary new understanding of happiness and well-being. Simon and Schuster; 2011. Seligman ME. Flourish: A visionary new understanding of happiness and well-being. Simon and Schuster; 2011.
140.
go back to reference Higgins ST, Heil SH, Peck KR. Substance use disorder. In: Barlow DH, editor. Clinical handbook of psychological disorders: a step-by-step treatment manual (6th ed.). essay. Guildford Press; 2021. Higgins ST, Heil SH, Peck KR. Substance use disorder. In: Barlow DH, editor. Clinical handbook of psychological disorders: a step-by-step treatment manual (6th ed.). essay. Guildford Press; 2021.
Metadata
Title
Mechanisms of Behavior Change for Functional Improvements in Cannabis Use Disorder Treatments: Current Science and Future Outlook
Authors
Bryant M. Stone
Brian J. Sherman
Publication date
09-05-2024
Publisher
Springer International Publishing
Published in
Current Addiction Reports / Issue 4/2024
Electronic ISSN: 2196-2952
DOI
https://doi.org/10.1007/s40429-024-00578-8