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03-01-2024 | Original Contribution

Mechanism of multi-organ compensation under different iodine intake in pregnant rats: results from a repeated-measures study of iodine metabolism

Authors: Min Fu, Haixia Zhang, Yuanpeng Gao, Rui Yang, Qi Meng, Qi Jin, Yuxuan Qi, Nuo Shi, Wanqi Zhang

Published in: European Journal of Nutrition | Issue 2/2024

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Abstract

Purpose

This study aimed to explore the differences in iodine metabolism and expression of NIS and Pendrin in pregnant rats under different iodine nutritional status.

Methods

Female Wistar rats were divided into four groups: low iodine (LI), normal iodine (NI), ten fold high iodine (10HI), and fifty fold high iodine (50HI). The intervention began after one week of adaptive feeding. Iodine metabolism experiments were performed beginning on the 15th day of pregnancy. 24-h iodine intake and excretion were calculated. The concentrations of iodine in urine, fecal, thyroid, and placenta were measured by ICP-MS. PCR and Western Blot were used to detect the mRNA levels and cell membrane protein of sodium/iodide symporter (NIS) and Pendrin in the small intestine, thyroid, kidney, and placenta.

Results

Fecal iodine excretion (FIE) and urinary iodine excretion (UIE) in the 50HI group were significantly higher than those in the NI group (P < 0.05). The NIS protein and mRNA in the kidney and small intestine have an upward trend in iodine deficiency and a downward trend in iodine excess. Thyroid and placental iodine storage in the 50HI group were significantly higher than those in the NI group (P < 0.05). NIS, Pendrin protein, and mRNA in the thyroid and placenta tend to increase when iodine is deficient and decrease when there is excess.

Conclusion

Iodine excretion and iodine stores in the placenta and thyroid gland are positively correlated with iodine intake. NIS and Pendrin are also regulated by iodine intake.
Appendix
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Literature
5.
go back to reference Abel MH, Caspersen IH, Meltzer HM, Haugen M, Brandlistuen RE, Aase H, Alexander J, Torheim LE, Brantsæter AL (2017) Suboptimal maternal iodine intake is associated with impaired child neurodevelopment at 3 years of age in the Norwegian mother and child cohort study. J Nutr 147(7):1314–1324. https://doi.org/10.3945/jn.117.250456CrossRefPubMed Abel MH, Caspersen IH, Meltzer HM, Haugen M, Brandlistuen RE, Aase H, Alexander J, Torheim LE, Brantsæter AL (2017) Suboptimal maternal iodine intake is associated with impaired child neurodevelopment at 3 years of age in the Norwegian mother and child cohort study. J Nutr 147(7):1314–1324. https://​doi.​org/​10.​3945/​jn.​117.​250456CrossRefPubMed
32.
Metadata
Title
Mechanism of multi-organ compensation under different iodine intake in pregnant rats: results from a repeated-measures study of iodine metabolism
Authors
Min Fu
Haixia Zhang
Yuanpeng Gao
Rui Yang
Qi Meng
Qi Jin
Yuxuan Qi
Nuo Shi
Wanqi Zhang
Publication date
03-01-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 2/2024
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-023-03288-5

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