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Published in: European Journal of Pediatrics 3/2023

21-01-2023 | Maxillary Augmentation | RESEARCH

Arterial stiffness indices, pulse wave velocity and central systolic blood pressure, are able to discriminate between obese and non-obese children

Authors: Juliana Cabral Bittencourt, Giovanna Hermont Abbes Scheinbein, Walmer Cardoso de Oliveira Junior, Roberta Leão Bassi, Luiza Bretas Moura, Ana Luisa Drumond Correa, Raquel Gil de Lima Bernardes, Leticia Silveira Freitas, Julia Correa Lemos, Gleisy Kelly Neves Gonçalves, Maria da Glória Rodrigues-Machado

Published in: European Journal of Pediatrics | Issue 3/2023

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Abstract

The objectives of this study were to verify, first, if arterial stiffness indices can discriminate between obese and healthy children. Second, to evaluate arterial stiffness index predictors and hemodynamic parameters in obese children. Arterial stiffness indices evaluated were pulse wave velocity (PWV), central systolic blood pressure (SBPc), and central pulse pressure (PPc). A cross-sectional, descriptive, comparative study design was used. The sample consisted of 78 normal-weight children (8.1 ± 1.96 years) and 58 obese children (9.0 ± 1.87 years). PWV, PPc, and SBPc were significantly higher in the group of obese children than in the control group. The ROC curve analysis showed that maximum PWV and SBPc sensitivity and specificity in differentiating obese from non-obese children occurred at 4.09 m/s and 86.17 mmHg, respectively. PPc did not exhibit a discriminatory capacity between the two groups. Peripheral systolic blood pressure (SBPp), peripheral pulse pressure (PPp), and PPc (R2 = 0.98) were predictors of increased PWV. Augmentation pressure, PPp, and reflection coefficient (R2 = 0.873) were predictors of PPc. Age, augmentation index, total vascular resistance, cardiac index, and mean fat percentage (R2 = 0.801) were predictors of SBPc.
Conclusion: This study shows for the first time that PWV > 4.09 m/s and SBPc > 86.17 mmHg are cut-off points associated with a higher risk of obesity. These results indicate that the simple, rapid, and noninvasive measurement of arterial stiffness adds prognostic information regarding cardiovascular risk, in addition to increased body mass index.
What is Known:
• Overweight and obesity are strongly associated with comorbidities que contribute to the development of cardiovascular diseases.
What is New:
• This is the first study to show that PWV and SBPc can discriminate obese from non-obese children. These results show that, in addition to an increased BMI, a simple, rapid, and noninvasive measurement of arterial stiffness adds prognostic information on cardiovascular risk.
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Metadata
Title
Arterial stiffness indices, pulse wave velocity and central systolic blood pressure, are able to discriminate between obese and non-obese children
Authors
Juliana Cabral Bittencourt
Giovanna Hermont Abbes Scheinbein
Walmer Cardoso de Oliveira Junior
Roberta Leão Bassi
Luiza Bretas Moura
Ana Luisa Drumond Correa
Raquel Gil de Lima Bernardes
Leticia Silveira Freitas
Julia Correa Lemos
Gleisy Kelly Neves Gonçalves
Maria da Glória Rodrigues-Machado
Publication date
21-01-2023
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics / Issue 3/2023
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-023-04807-6

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