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BMC Infectious Diseases
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Open Access 01-12-2024 | Systematic Review

Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis

Authors: Muhammed Shabil, Shilpa Gaidhane, Suhas Ballal, Sanjay Kumar, Mahakshit Bhat, Shilpa Sharma, M Ravi Kumar, Sarvesh Rustagi, Mahalaqua Nazli Khatib, Nishant Rai, Mohammed Garout, Nabiha A. Bouafia, Amer Alshengeti, Hayam A Alrasheed, Nawal A. Al Kaabi, Mubarak Alfaresi, Ali Hazazi, Ali A. Rabaan, Sanjit Sah, Sorabh Lakhanpal, Ganesh Bushi, Laksmi Thangavelu, Nagavalli Chilakam, Sakshi Pandey, Manvinder Brar, Rachana Mehta, Ashok Kumar Balaraman, Rukshar Syed, Gajendra Sharma

Published in: BMC Infectious Diseases | Issue 1/2024

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Abstract

Background

The COVID-19 pandemic has significantly impacted public health, with emerging evidence suggesting substantial effects on maternal and neonatal health. This systematic review and meta-analysis aimed to quantify the prevalence and risk of respiratory distress syndrome (RDS) in newborns born to mothers infected with SARS-CoV-2, the virus responsible for COVID-19.

Methods

We conducted a literature search in Embase, PubMed, and Web of Science up to April 20, without language or date restrictions. Observational studies reporting on the prevalence or risk of RDS among newborns from mothers with confirmed SARS-CoV-2 infection were included. Quality assessment was performed using the JBI tool. Statistical analysis was performed by using R software version 4.3.

Results

Twenty-two studies met the inclusion criteria. The pooled prevalence of RDS among newborns born to COVID-19-infected mothers was 11.5% (95% CI: 7.4–17.3%), with significant heterogeneity (I² = 93%). Newborns from infected mothers had a significantly higher risk of developing RDS, with a pooled risk ratio (RR) of 2.69 (95% CI: 1.77 to 4.17).

Conclusion

Newborns born to mothers with COVID-19 have a substantially increased risk of developing RDS. These findings emphasize the need for vigilant monitoring and appropriate management of pregnant women with COVID-19 to mitigate adverse neonatal outcomes.
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Metadata
Title
Maternal COVID-19 infection and risk of respiratory distress syndrome among newborns: a systematic review and meta-analysis
Authors
Muhammed Shabil
Shilpa Gaidhane
Suhas Ballal
Sanjay Kumar
Mahakshit Bhat
Shilpa Sharma
M Ravi Kumar
Sarvesh Rustagi
Mahalaqua Nazli Khatib
Nishant Rai
Mohammed Garout
Nabiha A. Bouafia
Amer Alshengeti
Hayam A Alrasheed
Nawal A. Al Kaabi
Mubarak Alfaresi
Ali Hazazi
Ali A. Rabaan
Sanjit Sah
Sorabh Lakhanpal
Ganesh Bushi
Laksmi Thangavelu
Nagavalli Chilakam
Sakshi Pandey
Manvinder Brar
Rachana Mehta
Ashok Kumar Balaraman
Rukshar Syed
Gajendra Sharma
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-024-10161-1

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