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03-01-2024 | Mast Cell Stabilizer | Original Contribution

Mast cell stabilizer, an anti-allergic drug, reduces ventricular arrhythmia risk via modulation of neuroimmune interaction

Authors: Yuhong Wang, Zhihao Liu, Wenjie Zhou, Jun Wang, Rui Li, Chen Peng, Liying Jiao, Song Zhang, Zhihao Liu, Zhongyang Yu, Ji Sun, Qiang Deng, Shoupeng Duan, Wuping Tan, Yijun Wang, Lingpeng Song, Fuding Guo, Zhen Zhou, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu

Published in: Basic Research in Cardiology | Issue 1/2024

Abstract

Mast cells (MCs) are important intermediates between the nervous and immune systems. The cardiac autonomic nervous system (CANS) crucially modulates cardiac electrophysiology and arrhythmogenesis, but whether and how MC-CANS neuroimmune interaction influences arrhythmia remain unclear. Our clinical data showed a close relationship between serum levels of MC markers and CANS activity, and then we use mast cell stabilizers (MCSs) to alter this MC-CANS communication. MCSs, which are well-known anti-allergic agents, could reduce the risk of ventricular arrhythmia (VA) after myocardial infarction (MI). RNA-sequencing (RNA-seq) analysis to investigate the underlying mechanism by which MCSs could affect the left stellate ganglion (LSG), a key therapeutic target for modulating CANS, showed that the IL-6 and γ-aminobutyric acid (GABA)-ergic system may be involved in this process. Our findings demonstrated that MCSs reduce VA risk along with revealing the potential underlying antiarrhythmic mechanisms.

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Title: Mast cell stabilizer, an anti-allergic drug, reduces ventricular arrhythmia risk via modulation of neuroimmune interaction
Authors: Yuhong Wang
Zhihao Liu
Wenjie Zhou
Jun Wang
Rui Li
Chen Peng
Liying Jiao
Song Zhang
Zhihao Liu
Zhongyang Yu
Ji Sun
Qiang Deng
Shoupeng Duan
Wuping Tan
Yijun Wang
Lingpeng Song
Fuding Guo
Zhen Zhou
Yueyi Wang
Liping Zhou
Hong Jiang
Lilei Yu
Publication date: 03-01-2024
Publisher: Springer Berlin Heidelberg
Keywords: Mast Cell Stabilizer
Myocardial Infarction
CSF Drainage
Published in: Basic Research in Cardiology / Issue 1/2024
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-023-01024-y

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