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03-02-2025 | Malnutrition | Nephrology – Review

Effect of selenium supplementation on hemodialysis patients: a meta-analysis

Authors: Qiu Cheng, Dandan Fan, Pengyu Chen, Huaihong Yuan

Published in: International Urology and Nephrology

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Abstract

Purpose

Hemodialysis (HD) patients commonly experience enhanced oxidative stress and inflammation, potentially increasing the risk of malnutrition. Selenium levels are typically lower in HD individuals. Selenium deficiency has been identified as a risk factor for oxidative stress and inflammatory responses. Therefore, we intended to perform a meta-analysis to assess the impact of selenium supplementation on HD patients.

Methods

PubMed, Embase, Cochrane Library, and Web of Science were searched for randomized controlled trials (RCTs) on the effect of selenium supplementation on HD patients until September 31, 2024. The data analysis was conducted using Stata15.0 software.

Results

Seven RCTs, with 2080 participants, were finally included, with 1029 in the selenium group and 1051 in the control group. The meta-analysis unraveled no statistically significant impact of selenium supplementation on body mass index (SMD = 0.15, 95% CI (− 0.20, 0.49), triglyceride [(SMD = − 0.02, 95% CI (− 0.44, 0.41)], total cholesterol [(SMD = − 0.18, 95%CI (− 0.41, 0.05)], low-density lipoprotein [(SMD = − 0.37, 95% CI (− 1.04, 0.31)], high-density lipoprotein cholesterol [(SMD = 0.15, 95% CI (− 0.54, 0.84)], C-reactive protein [(SMD = − 0.10, 95% CI (− 0.46, 0.27)], ferritin [(SMD = − 0.02, 95% CI (− 0.29, 0.26)], Hx-C reactive protein [(SMD = 0.00, 95% CI (− 1.02, 1.03)], and hemoglobin [(SMD = 0.01, 95% CI (− 0.57,0.59)]. Only selenium levels were significantly increased after selenium supplementation [SMD = 2.83, 95% CI (2.43, 3.24)].

Conclusion

Selenium supplementation can increase selenium levels in HD patients, without notable impacts on weight, triglycerides, and total cholesterol.
Appendix
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Literature
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Metadata
Title
Effect of selenium supplementation on hemodialysis patients: a meta-analysis
Authors
Qiu Cheng
Dandan Fan
Pengyu Chen
Huaihong Yuan
Publication date
03-02-2025
Publisher
Springer Netherlands
Keyword
Malnutrition
Published in
International Urology and Nephrology
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-025-04400-w

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