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10-09-2022 | Magnetic Resonance Imaging | Original Article

Cortical change after a 2-week novel robotic rehabilitation program in children with prior hemispherectomy: pilot imaging study

Authors: Saman Hazany, Daljit Mann, Neelesh Bagrodia, Anthony J. Krafnick, Remy Chu Jr., Susan Shaw, Kristi Clark

Published in: Child's Nervous System | Issue 2/2023

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Abstract

Introduction

Partial preservation of sensory and motor functions in the contralateral extremities after hemispherectomy is likely secondary to cortical reorganization of the remaining hemisphere and can be improved by rehabilitation. This study aims to investigate behavioral and structural cerebral cortical changes that may occur after a 2-week novel robotic rehabilitation program in children with prior anatomic hemispherectomy.

Methods

Five patients with prior anatomic hemispherectomy (average age 10.8 years; all female) participated in a 2-week novel robotic rehabilitation program. Pre- and post-treatment (2 time points) high-resolution structural 3D FSPGR (fast spoiled gradient echo) magnetic resonance images were analyzed to measure cortical thickness and gray matter volume using a locally designed image processing pipeline.

Results

Four of the five patients showed improvement in the Fugl-Meyer score (average increase 2.5 + 2.1 SD. Individual analyses identified small increases in gray matter volume near the hand knob area of the primary cortex in three of the five patients. Group analyses identified an increase in cortical thickness near the hand knob area of the primary motor cortex, in addition to other sensorimotor regions.

Conclusion

This small pilot study demonstrates that potentially rehabilitation-associated cortical changes can be identified with MRI in hemispherectomy patients.
Literature
8.
go back to reference de Bode S, Firestine A, Mathern GW, Dobkin B (2005) Residual motor control and cortical representations of function following hemispherectomy: effects of etiology. J Child Neurol 20(1):64–75CrossRefPubMed de Bode S, Firestine A, Mathern GW, Dobkin B (2005) Residual motor control and cortical representations of function following hemispherectomy: effects of etiology. J Child Neurol 20(1):64–75CrossRefPubMed
9.
go back to reference Holloway V, Gadian DG, Vargha-Khadem F, Porter DA, Boyd SG, Connelly A (2020) The reorganization of sensorimotor function in children after hemispherectomy. A functional MRI and somatosensory evoked potential study. Brain J Neurol 123(Pt 12):2432–2444 Holloway V, Gadian DG, Vargha-Khadem F, Porter DA, Boyd SG, Connelly A (2020) The reorganization of sensorimotor function in children after hemispherectomy. A functional MRI and somatosensory evoked potential study. Brain J Neurol 123(Pt 12):2432–2444
11.
go back to reference Graveline CJ, Mikulis DJ, Crawley AP, Hwang PA (1998) Regionalized sensorimotor plasticity after hemispherectomy fMRI evaluation. Pediatr Neurol 19(5):337–342CrossRefPubMed Graveline CJ, Mikulis DJ, Crawley AP, Hwang PA (1998) Regionalized sensorimotor plasticity after hemispherectomy fMRI evaluation. Pediatr Neurol 19(5):337–342CrossRefPubMed
13.
go back to reference Rutten GJ, Ramsey NF, van Rijen PC, Franssen H, van Veelen CW (2002) Interhemispheric reorganization of motor hand function to the primary motor cortex predicted with functional magnetic resonance imaging and transcranial magnetic stimulation. J Child Neurol 17(4):292–297CrossRefPubMed Rutten GJ, Ramsey NF, van Rijen PC, Franssen H, van Veelen CW (2002) Interhemispheric reorganization of motor hand function to the primary motor cortex predicted with functional magnetic resonance imaging and transcranial magnetic stimulation. J Child Neurol 17(4):292–297CrossRefPubMed
15.
go back to reference Bernasconi A, Bernasconi N, Lassonde M et al (2000) Sensorimotor organization in patients who have undergone hemispherectomy: a study with (15)O-water PET and somatosensory evoked potentials. Neuroreport 11(14):3085–3090CrossRefPubMed Bernasconi A, Bernasconi N, Lassonde M et al (2000) Sensorimotor organization in patients who have undergone hemispherectomy: a study with (15)O-water PET and somatosensory evoked potentials. Neuroreport 11(14):3085–3090CrossRefPubMed
17.
go back to reference Wakamoto H, Eluvathingal TJ, Makki M, Juhasz C, Chugani HT (2006) Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 21(7):566–571CrossRefPubMed Wakamoto H, Eluvathingal TJ, Makki M, Juhasz C, Chugani HT (2006) Diffusion tensor imaging of the corticospinal tract following cerebral hemispherectomy. J Child Neurol 21(7):566–571CrossRefPubMed
19.
go back to reference Jacokes Z, Bhattrai A, Torgerson C et al (2016) Chapter 12: The neuroimaging challenges in hemispherectomy patients. Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management 4th ed. Springer Jacokes Z, Bhattrai A, Torgerson C et al (2016) Chapter 12: The neuroimaging challenges in hemispherectomy patients. Traumatic Brain Injury: Rehabilitation, Treatment, and Case Management 4th ed. Springer
21.
go back to reference Smith SM, De Stefano N, Jenkinson M, Matthews PM (2001) Normalized accurate measurement of longitudinal brain change. Research Support, Non-U.S. Gov't. J Comput Assist 25(3):466–475 Smith SM, De Stefano N, Jenkinson M, Matthews PM (2001) Normalized accurate measurement of longitudinal brain change. Research Support, Non-U.S. Gov't. J Comput Assist 25(3):466–475
22.
go back to reference Smith SM, Zhang Y, Jenkinson M et al (2002) Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 17(1):479–489CrossRefPubMed Smith SM, Zhang Y, Jenkinson M et al (2002) Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 17(1):479–489CrossRefPubMed
23.
go back to reference Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2):825–841CrossRefPubMed Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2):825–841CrossRefPubMed
24.
go back to reference Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5(2):143–156CrossRefPubMed Jenkinson M, Smith S (2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5(2):143–156CrossRefPubMed
25.
go back to reference Zhang Y, Brady M, Smith S (2001) Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20(1):45–57CrossRefPubMed Zhang Y, Brady M, Smith S (2001) Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 20(1):45–57CrossRefPubMed
26.
go back to reference Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. NeuroImage 9(2):195–207. Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. NeuroImage 9(2):195–207.
41.
go back to reference Han K, Davis RA, Chapman SB, Krawczyk DC (2017) Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury. Brain Behav 7(5):e00687. https://doi.org/10.1002/brb3.687 Han K, Davis RA, Chapman SB, Krawczyk DC (2017) Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury. Brain Behav 7(5):e00687. https://​doi.​org/​10.​1002/​brb3.​687
43.
Metadata
Title
Cortical change after a 2-week novel robotic rehabilitation program in children with prior hemispherectomy: pilot imaging study
Authors
Saman Hazany
Daljit Mann
Neelesh Bagrodia
Anthony J. Krafnick
Remy Chu Jr.
Susan Shaw
Kristi Clark
Publication date
10-09-2022
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 2/2023
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-022-05664-8

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