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Graefe's Archive for Clinical and Experimental Ophthalmology

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13-02-2024 | Macular Degeneration | Retinal Disorders

Factors associated with the development of exudation in treatment-naive eyes with nonexudative macular neovascularization

Authors: Han Joo Cho, Minchul Kim, Jeongmin Kim, Isang Yoon, Sangmin Park, Chul Gu Kim

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2024

Abstract

Purpose

To identify the predictive factors for development of exudation in patients with treatment-naïve nonexudative macular neovascularization (MNV).

Methods

We retrospectively analyzed 61 treatment-naïve patients with nonexudative MNV who had not received treatment for nonexudative MNV before the exudation developed. Baseline characteristics and changes in MNV were evaluated using multivariate modeling to determine the potential risk factors for exudative conversion.

Results

Exudation development was identified in 31.1% (19/61 eyes) of the study eyes during the 46.2 ± 8.2-month mean follow-up period. The mean period of development of exudation from the baseline was 21.5 ± 6.7 months. Multivariate Cox regression analysis identified that older age (hazard ratio [HR] of 1.380, 95% confidence interval [CI] 1.129–1.688, P = 0.008), larger MNV area at baseline (HR of 1.715, CI 1.288–2.308; P = 0.006), increase of MNV area by doubling (HR of 4.992, CI 1.932–9.246; P = 0.002), and retinal pigment epithelium (RPE) elevation more than 100 μm (HR of 1.017, CI 1.006–1.233; P = 0.015) were associated with increased risk of the development of exudation.

Conclusion

Older age, larger MNV area, increasing MNV area, and higher RPE elevation were associated with an increased risk of exudative conversion in patients with treatment-naïve nonexudative MNV. Identifying these risk factors may be helpful in establishing treatment strategies and monitoring patients.

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Title: Factors associated with the development of exudation in treatment-naive eyes with nonexudative macular neovascularization
Authors: Han Joo Cho
Minchul Kim
Jeongmin Kim
Isang Yoon
Sangmin Park
Chul Gu Kim
Publication date: 13-02-2024
Publisher: Springer Berlin Heidelberg
Keywords: Macular Degeneration
Angiography
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2024
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-024-06384-2

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