A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review

Open Access
04-11-2024
Lymphoma
Case Report

Published in:

Authors: Yuzhan Chen; Ting Chen; Shufang Fan; Qitian Mu; Guifang Ouyang
Published in: Annals of Hematology | Issue 2/2025

Abstract

In indolent lymphomas, histological transformation (HT) often results in a poor prognosis and presents a significant challenge in the management of these lymphomas. Previous studies have indicated that MYD88 mutations are associated with transformation in certain haematologic malignancies. We report a rare case of splenic marginal zone lymphoma (SMZL) harbouring an MYD88 mutation, which was transformed into diffuse large B-cell lymphoma (DLBCL) and accompanied by newly emerging genetic abnormalities. The role of the MYD88 gene in SMZL is currently unclear. Through this case, we reviewed relevant studies, which indicated that MYD88 mutations, along with other genetic anomalies, may play a significant role in this process. In the future, it is essential to collect more of these rare cases for further research.

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Metadata
Literature

Title: A rare case of splenic marginal zone lymphoma with MYD88 mutation transformed into diffuse large B-cell lymphoma: case report and literature review
Authors: Yuzhan Chen
Ting Chen
Shufang Fan
Qitian Mu
Guifang Ouyang
Publication date: 04-11-2024
Publisher: Springer Berlin Heidelberg
Keywords: Lymphoma
Diffuse Large B-Cell Lymphoma
Molecular Genetics
Diffuse Large B-Cell Lymphoma
Non-Hodgkin Lymphoma
Published in: Annals of Hematology / Issue 2/2025
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI: https://doi.org/10.1007/s00277-024-06080-5

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