The association between sleep quantity, insomnia and lung cancer risk – A systematic review and meta-analysis
- 15-08-2024
- Lung Cancer
- Sleep Breathing Physiology and Disorders • Review
Published in:
- Authors
- Brian Sheng Yep Yeo
- Jin Hean Koh
- Bryan Yichong Shi
- Jun He Chan
- Adele Chin Wei Ng
- Shaun Loh
- Leong Chai Leow
- Thun How Ong
- Joshua J. Gooley
- Song Tar Toh
- Published in
- Sleep and Breathing | Issue 6/2024
Abstract
Purpose
The effect of various sleep traits on the risk of lung cancer differs among pre-existing studies. This study aims to systematically review and synthesise the association between sleep duration and insomnia with the incidence of lung cancer.
Methods
PubMed, Embase and The Cochrane Library were searched from inception to 23 April 2023 for observational studies examining the effect of sleep quantity or insomnia on lung cancer incidence. We pooled maximally-adjusted hazard ratios and odds ratios separately using random effects inverse variance weighted models. The risk of bias of observational studies was assessed using the Newcastle–Ottawa Scale.
Results
We included 11 observational studies with a pooled cohort of 5,049,141 patients. The mean age of the patients was 49.5 ± 17.7 years, and 51.4% were males. The risk of bias ranged from low-moderate. Individuals who slept for a shorter or longer duration than the reference range of sleep per night showed an increased risk of lung cancer by 11% (HR:1.11; 95%CI:1.00–1.23) and 16% (HR:1.16; 95%CI:1.06–1.27) respectively. Furthermore, individuals with insomnia symptoms had a 9% greater risk of lung cancer than those without symptoms (HR:1.09; 95%CI:1.05–1.13).
Conclusion
This study suggests that insufficient sleep, excessive sleep and insomnia may be associated with an increased risk of lung cancer. Physicians should be mindful of this association and encourage healthy sleep practises among patients. Given the observed heterogeneity among some pre-existing studies, future research with longer periods of follow-up, greater control for covariates and objective testing of sleep parameters may add value to this topic.
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- Title
- The association between sleep quantity, insomnia and lung cancer risk – A systematic review and meta-analysis
- Authors
-
Brian Sheng Yep Yeo
Jin Hean Koh
Bryan Yichong Shi
Jun He Chan
Adele Chin Wei Ng
Shaun Loh
Leong Chai Leow
Thun How Ong
Joshua J. Gooley
Song Tar Toh
- Publication date
- 15-08-2024
- Publisher
- Springer International Publishing
- Published in
-
Sleep and Breathing / Issue 6/2024
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709 - DOI
- https://doi.org/10.1007/s11325-024-03092-3
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