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Open Access 26-12-2023 | Long-COVID Syndrome | Original Paper

Impact of Long COVID on productivity and informal caregiving

Authors: Joseph Kwon, Ruairidh Milne, Clare Rayner, Román Rocha Lawrence, Jordan Mullard, Ghazala Mir, Brendan Delaney, Manoj Sivan, Stavros Petrou

Published in: The European Journal of Health Economics | Issue 7/2024

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Abstract

Background

Around 2 million people in the UK suffer from Long COVID (LC). Of concern is the disease impact on productivity and informal care burden. This study aimed to quantify and value productivity losses and informal care receipt in a sample of LC patients in the UK.

Methods

The target population comprised LC patients referred to LC specialist clinics. The questionnaires included a health economics questionnaire (HEQ) measuring productivity impacts, informal care receipt and service utilisation, EQ-5D-5L, C19-YRS LC condition-specific measure, and sociodemographic and COVID-19 history variables. Outcomes were changes from the incident infection resulting in LC to the month preceding the survey in paid work status/h, work income, work performance and informal care receipt. The human capital approach valued productivity losses; the proxy goods method valued caregiving hours. The values were extrapolated nationally using published prevalence data. Multilevel regressions, nested by region, estimated associations between the outcomes and patient characteristics.

Results

366 patients responded to HEQ (mean LC duration 449.9 days). 51.7% reduced paid work hours relative to the pre-infection period. Mean monthly work income declined by 24.5%. The average aggregate value of productivity loss since incident infection was £10,929 (95% bootstrap confidence interval £8,844-£13,014) and £5.7 billion (£3.8-£7.6 billion) extrapolated nationally. The corresponding values for informal caregiving were £8,726 (£6,247-£11,204) and £4.8 billion (£2.6-£7.0 billion). Multivariate analyses found significant associations between each outcome and health utility and C19-YRS subscale scores.

Conclusion

LC significantly impacts productivity losses and provision of informal care, exacerbated by high national prevalence of LC.
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Literature
1.
go back to reference National Institute for Health and Care Excellence, Scottish Intercollegiate Guidelines Network, Royal College of General Practitioners. COVID-19 rapid guideline: managing the long-term effects of COVID-19. In: NICE R, and SIGN, editor. 2022. National Institute for Health and Care Excellence, Scottish Intercollegiate Guidelines Network, Royal College of General Practitioners. COVID-19 rapid guideline: managing the long-term effects of COVID-19. In: NICE R, and SIGN, editor. 2022.
2.
go back to reference Office for National Statistics. Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 30 March 2023. 2023. Office for National Statistics. Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK: 30 March 2023. 2023.
3.
go back to reference Sivan, M., Preston, N., Parkin, A., Makower, S., Gee, J., Ross, D., et al.: The modified COVID-19 Yorkshire rehabilitation scale (C19-YRSm) patient-reported outcome measure for long covid or post-COVID-19 syndrome. J. Med. Virol. 94(9), 4253–4264 (2022)PubMedPubMedCentralCrossRef Sivan, M., Preston, N., Parkin, A., Makower, S., Gee, J., Ross, D., et al.: The modified COVID-19 Yorkshire rehabilitation scale (C19-YRSm) patient-reported outcome measure for long covid or post-COVID-19 syndrome. J. Med. Virol. 94(9), 4253–4264 (2022)PubMedPubMedCentralCrossRef
4.
go back to reference Pierce, J.D., Shen, Q., Cintron, S.A., Hiebert, J.B.: Post-COVID-19 syndrome. Nurs. Res. 71(2), 164–174 (2022)PubMedCrossRef Pierce, J.D., Shen, Q., Cintron, S.A., Hiebert, J.B.: Post-COVID-19 syndrome. Nurs. Res. 71(2), 164–174 (2022)PubMedCrossRef
5.
go back to reference Michelen, M., Manoharan, L., Elkheir, N., Cheng, V., Dagens, A., Hastie, C., et al.: Characterising long COVID: a living systematic review. BMJ Glob. Health 6(9), e005427 (2021)PubMedCrossRef Michelen, M., Manoharan, L., Elkheir, N., Cheng, V., Dagens, A., Hastie, C., et al.: Characterising long COVID: a living systematic review. BMJ Glob. Health 6(9), e005427 (2021)PubMedCrossRef
6.
go back to reference Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, et al. Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study. Bmj. 2022; 377. Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, et al. Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study. Bmj. 2022; 377.
7.
go back to reference Brown, D.A., O’Brien, K.K.: Conceptualising long COVID as an episodic health condition. BMJ Glob. Health 6(9), e007004 (2021)PubMedCrossRef Brown, D.A., O’Brien, K.K.: Conceptualising long COVID as an episodic health condition. BMJ Glob. Health 6(9), e007004 (2021)PubMedCrossRef
8.
go back to reference All-Party Parliamentary Group. Long COVID Report March 2022. In: Group A-PP, editor. 2022. All-Party Parliamentary Group. Long COVID Report March 2022. In: Group A-PP, editor. 2022.
9.
go back to reference Davis, H.E., Assaf, G.S., McCorkell, L., Wei, H., Low, R.J., Re’em, Y., et al.: Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 38, 101019 (2021)PubMedPubMedCentralCrossRef Davis, H.E., Assaf, G.S., McCorkell, L., Wei, H., Low, R.J., Re’em, Y., et al.: Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine. 38, 101019 (2021)PubMedPubMedCentralCrossRef
10.
go back to reference Walker, S., Goodfellow, H., Pookarnjanamorakot, P., Murray, E., Bindman, J., Blandford, A., et al.: Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open 13(6), e069217 (2023)PubMedPubMedCentralCrossRef Walker, S., Goodfellow, H., Pookarnjanamorakot, P., Murray, E., Bindman, J., Blandford, A., et al.: Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open 13(6), e069217 (2023)PubMedPubMedCentralCrossRef
11.
go back to reference Reuschke D, Houston D. The impact of Long COVID on the UK workforce. Applied Economics Letters. 2022:1–5. Reuschke D, Houston D. The impact of Long COVID on the UK workforce. Applied Economics Letters. 2022:1–5.
12.
go back to reference Kerksieck P, Ballouz T, Haile SR, Schumacher C, Lacy J, Domenghino A, et al. Post COVID-19 condition, work ability and occupational changes in a population-based cohort. The Lancet Regional Health–Europe. 2023. Kerksieck P, Ballouz T, Haile SR, Schumacher C, Lacy J, Domenghino A, et al. Post COVID-19 condition, work ability and occupational changes in a population-based cohort. The Lancet Regional Health–Europe. 2023.
13.
go back to reference Delgado-Alonso, C., Cuevas, C., Oliver-Mas, S., Díez-Cirarda, M., Delgado-Álvarez, A., Gil-Moreno, M.J., et al.: Fatigue and cognitive dysfunction are associated with occupational status in post-COVID syndrome. Int. J. Environ. Res. Public Health 19(20), 13368 (2022)PubMedPubMedCentralCrossRef Delgado-Alonso, C., Cuevas, C., Oliver-Mas, S., Díez-Cirarda, M., Delgado-Álvarez, A., Gil-Moreno, M.J., et al.: Fatigue and cognitive dysfunction are associated with occupational status in post-COVID syndrome. Int. J. Environ. Res. Public Health 19(20), 13368 (2022)PubMedPubMedCentralCrossRef
14.
go back to reference Magnavita, N., Arnesano, G., Di Prinzio, R.R., Gasbarri, M., Meraglia, I., Merella, M., et al.: Post-COVID symptoms in occupational cohorts: effects on health and work ability. Int. J. Environ. Res. Public Health 20(9), 5638 (2023)PubMedPubMedCentralCrossRef Magnavita, N., Arnesano, G., Di Prinzio, R.R., Gasbarri, M., Meraglia, I., Merella, M., et al.: Post-COVID symptoms in occupational cohorts: effects on health and work ability. Int. J. Environ. Res. Public Health 20(9), 5638 (2023)PubMedPubMedCentralCrossRef
15.
go back to reference Vaes AW, Goërtz YM, Van Herck M, Machado FV, Meys R, Delbressine JM, et al. Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members. ERJ open research. 2021;7 (2). Vaes AW, Goërtz YM, Van Herck M, Machado FV, Meys R, Delbressine JM, et al. Recovery from COVID-19: a sprint or marathon? 6-month follow-up data from online long COVID-19 support group members. ERJ open research. 2021;7 (2).
16.
go back to reference Westerlind, E., Palstam, A., Sunnerhagen, K.S., Persson, H.C.: Patterns and predictors of sick leave after COVID-19 and long COVID in a national Swedish cohort. BMC Public Health 21(1), 1–9 (2021)CrossRef Westerlind, E., Palstam, A., Sunnerhagen, K.S., Persson, H.C.: Patterns and predictors of sick leave after COVID-19 and long COVID in a national Swedish cohort. BMC Public Health 21(1), 1–9 (2021)CrossRef
17.
go back to reference Buonsenso, D., Gualano, M.R., Rossi, M.F., Valz Gris, A., Sisti, L.G., Borrelli, I., et al.: Post-acute COVID-19 sequelae in a working population at one year follow-Up: a wide range of impacts from an italian sample. Int. J. Environ. Res. Public Health 19(17), 11093 (2022)PubMedPubMedCentralCrossRef Buonsenso, D., Gualano, M.R., Rossi, M.F., Valz Gris, A., Sisti, L.G., Borrelli, I., et al.: Post-acute COVID-19 sequelae in a working population at one year follow-Up: a wide range of impacts from an italian sample. Int. J. Environ. Res. Public Health 19(17), 11093 (2022)PubMedPubMedCentralCrossRef
18.
go back to reference Diem, L., Schwarzwald, A., Friedli, C., Hammer, H., Gomes-Fregolente, L., Warncke, J., et al.: Multidimensional phenotyping of the post-COVID-19 syndrome: a swiss survey study. CNS Neurosci. Ther. 28(12), 1953–1963 (2022)PubMedPubMedCentralCrossRef Diem, L., Schwarzwald, A., Friedli, C., Hammer, H., Gomes-Fregolente, L., Warncke, J., et al.: Multidimensional phenotyping of the post-COVID-19 syndrome: a swiss survey study. CNS Neurosci. Ther. 28(12), 1953–1963 (2022)PubMedPubMedCentralCrossRef
19.
go back to reference Dryden, M., Mudara, C., Vika, C., Blumberg, L., Mayet, N., Cohen, C., et al.: Post-COVID-19 condition 3 months after hospitalisation with SARS-CoV-2 in South Africa: a prospective cohort study. Lancet Glob. Health 10(9), e1247–e1256 (2022)PubMedPubMedCentralCrossRef Dryden, M., Mudara, C., Vika, C., Blumberg, L., Mayet, N., Cohen, C., et al.: Post-COVID-19 condition 3 months after hospitalisation with SARS-CoV-2 in South Africa: a prospective cohort study. Lancet Glob. Health 10(9), e1247–e1256 (2022)PubMedPubMedCentralCrossRef
20.
go back to reference Kisiel MA, Janols H, Nordqvist T, Bergquist J, Hagfeldt S, Malinovschi A, et al. Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability. Upsala Journal of Medical Sciences. 2022; 127. Kisiel MA, Janols H, Nordqvist T, Bergquist J, Hagfeldt S, Malinovschi A, et al. Predictors of post-COVID-19 and the impact of persistent symptoms in non-hospitalized patients 12 months after COVID-19, with a focus on work ability. Upsala Journal of Medical Sciences. 2022; 127.
21.
go back to reference Lunt J, Hemming S, Burton K, Elander J, Baraniak A. What workers can tell us about post-COVID workability. Occupational Medicine (Oxford, England). 2022. Lunt J, Hemming S, Burton K, Elander J, Baraniak A. What workers can tell us about post-COVID workability. Occupational Medicine (Oxford, England). 2022.
22.
go back to reference Mazer B, Feldman DE. Functional limitations in individuals with long COVID. Archives of Physical Medicine and Rehabilitation. 2023. Mazer B, Feldman DE. Functional limitations in individuals with long COVID. Archives of Physical Medicine and Rehabilitation. 2023.
23.
go back to reference Miskowiak, K., Pedersen, J., Gunnarsson, D., Roikjer, T., Podlekareva, D., Hansen, H., et al.: Cognitive impairments among patients in a long-COVID clinic: Prevalence, pattern and relation to illness severity, work function and quality of life. J. Affect. Disord. 324, 162–169 (2023)PubMedCrossRef Miskowiak, K., Pedersen, J., Gunnarsson, D., Roikjer, T., Podlekareva, D., Hansen, H., et al.: Cognitive impairments among patients in a long-COVID clinic: Prevalence, pattern and relation to illness severity, work function and quality of life. J. Affect. Disord. 324, 162–169 (2023)PubMedCrossRef
24.
go back to reference Perlis RH, Trujillo KL, Safarpour A, Santillana M, Ognyanova K, Druckman J, et al. Association of post–COVID-19 condition symptoms and employment status. JAMA network open 2023; 6 (2): e2256152-e. Perlis RH, Trujillo KL, Safarpour A, Santillana M, Ognyanova K, Druckman J, et al. Association of post–COVID-19 condition symptoms and employment status. JAMA network open 2023; 6 (2): e2256152-e.
25.
go back to reference Sansone, D., Tassinari, A., Valentinotti, R., Kontogiannis, D., Ronchese, F., Centonze, S., et al.: Persistence of symptoms 15 months since COVID-19 diagnosis: prevalence, risk factors and residual work ability. Life. 13(1), 97 (2022)PubMedPubMedCentralCrossRef Sansone, D., Tassinari, A., Valentinotti, R., Kontogiannis, D., Ronchese, F., Centonze, S., et al.: Persistence of symptoms 15 months since COVID-19 diagnosis: prevalence, risk factors and residual work ability. Life. 13(1), 97 (2022)PubMedPubMedCentralCrossRef
26.
go back to reference Yelin, D., Margalit, I., Nehme, M., Bordas-Martínez, J., Pistelli, F., Yahav, D., et al.: Patterns of long COVID symptoms: a multi-center cross sectional study. J. Clin. Med. 11(4), 898 (2022)PubMedPubMedCentralCrossRef Yelin, D., Margalit, I., Nehme, M., Bordas-Martínez, J., Pistelli, F., Yahav, D., et al.: Patterns of long COVID symptoms: a multi-center cross sectional study. J. Clin. Med. 11(4), 898 (2022)PubMedPubMedCentralCrossRef
27.
go back to reference Van Wambeke, E., Bezler, C., Kasprowicz, A.-M., Charles, A.-L., Andres, E., Geny, B.: Two-years follow-up of symptoms and return to work in complex post-COVID-19 patients. J. Clin. Med. 12(3), 741 (2023)PubMedPubMedCentralCrossRef Van Wambeke, E., Bezler, C., Kasprowicz, A.-M., Charles, A.-L., Andres, E., Geny, B.: Two-years follow-up of symptoms and return to work in complex post-COVID-19 patients. J. Clin. Med. 12(3), 741 (2023)PubMedPubMedCentralCrossRef
28.
go back to reference Ziauddeen, N., Gurdasani, D., O’Hara, M.E., Hastie, C., Roderick, P., Yao, G., et al.: Characteristics and impact of long covid: findings from an online survey. PLoS ONE 17(3), e0264331 (2022)PubMedPubMedCentralCrossRef Ziauddeen, N., Gurdasani, D., O’Hara, M.E., Hastie, C., Roderick, P., Yao, G., et al.: Characteristics and impact of long covid: findings from an online survey. PLoS ONE 17(3), e0264331 (2022)PubMedPubMedCentralCrossRef
29.
go back to reference Fischer, K., Reade, J.J., Schmal, W.B.: What cannot be cured must be endured: the long-lasting effect of a COVID-19 infection on workplace productivity. Labour Econ. 79, 102281 (2022)PubMedPubMedCentralCrossRef Fischer, K., Reade, J.J., Schmal, W.B.: What cannot be cured must be endured: the long-lasting effect of a COVID-19 infection on workplace productivity. Labour Econ. 79, 102281 (2022)PubMedPubMedCentralCrossRef
30.
go back to reference Fouad MM, Zawilla NH, Maged LA. Work performance among healthcare workers with post COVID-19 syndrome and its relation to antibody response. Infection. 2022: 1–11. Fouad MM, Zawilla NH, Maged LA. Work performance among healthcare workers with post COVID-19 syndrome and its relation to antibody response. Infection. 2022: 1–11.
31.
go back to reference Nehme, M., Vieux, L., Kaiser, L., Chappuis, F., Chenaud, C., Guessous, I.: The longitudinal study of subjective wellbeing and absenteeism of healthcare workers considering post-COVID condition and the COVID-19 pandemic toll. Sci. Rep. 13(1), 10759 (2023)PubMedPubMedCentralCrossRef Nehme, M., Vieux, L., Kaiser, L., Chappuis, F., Chenaud, C., Guessous, I.: The longitudinal study of subjective wellbeing and absenteeism of healthcare workers considering post-COVID condition and the COVID-19 pandemic toll. Sci. Rep. 13(1), 10759 (2023)PubMedPubMedCentralCrossRef
32.
go back to reference Levkovich, I., Kalimi, E.: Long COVID-19 symptoms among recovered teachers in israel: a mixed-methods study. COVID. 3(4), 480–493 (2023)CrossRef Levkovich, I., Kalimi, E.: Long COVID-19 symptoms among recovered teachers in israel: a mixed-methods study. COVID. 3(4), 480–493 (2023)CrossRef
33.
go back to reference Peters, C., Dulon, M., Westermann, C., Kozak, A., Nienhaus, A.: Long-term effects of COVID-19 on workers in health and social services in Germany. Int. J. Environ. Res. Public Health 19(12), 6983 (2022)PubMedPubMedCentralCrossRef Peters, C., Dulon, M., Westermann, C., Kozak, A., Nienhaus, A.: Long-term effects of COVID-19 on workers in health and social services in Germany. Int. J. Environ. Res. Public Health 19(12), 6983 (2022)PubMedPubMedCentralCrossRef
34.
go back to reference Dahlgren G, Whitehead M. European strategies for tackling social inequities in health: Levelling up Part 2. WHO Regional office for Europe Copenhagen; 2006. Dahlgren G, Whitehead M. European strategies for tackling social inequities in health: Levelling up Part 2. WHO Regional office for Europe Copenhagen; 2006.
35.
go back to reference Department of Health. Healthy lives, healthy people: Our strategy for public health in England: The Stationery Office; 2010. Department of Health. Healthy lives, healthy people: Our strategy for public health in England: The Stationery Office; 2010.
36.
go back to reference Mureșan, G.-M., Văidean, V.-L., Mare, C., Achim, M.V.: Were we happy and we didn’t know it? a subjective dynamic and financial assessment pre-, during and post-COVID-19. Eur. J. Health Econ. 24(5), 749–768 (2023)PubMedCrossRef Mureșan, G.-M., Văidean, V.-L., Mare, C., Achim, M.V.: Were we happy and we didn’t know it? a subjective dynamic and financial assessment pre-, during and post-COVID-19. Eur. J. Health Econ. 24(5), 749–768 (2023)PubMedCrossRef
39.
go back to reference Cook J. The socio‐economic contribution of older people in the UK. Working with Older People. 2011. Cook J. The socio‐economic contribution of older people in the UK. Working with Older People. 2011.
40.
go back to reference NHS England. National Commissioning Guidance for Post COVID Services. In: England N, editor. Version 3, July 20222022. NHS England. National Commissioning Guidance for Post COVID Services. In: England N, editor. Version 3, July 20222022.
41.
go back to reference Cohen, S.A., Kunicki, Z.J., Drohan, M.M., Greaney, M.L.: Exploring changes in caregiver burden and caregiving intensity due to COVID-19. Geront Geriatric Med. 7, 2333721421999279 (2021)CrossRef Cohen, S.A., Kunicki, Z.J., Drohan, M.M., Greaney, M.L.: Exploring changes in caregiver burden and caregiving intensity due to COVID-19. Geront Geriatric Med. 7, 2333721421999279 (2021)CrossRef
42.
go back to reference Koopmanschap, M.A., van Exel, N.J.A., van den Berg, B., Brouwer, W.B.: An overview of methods and applications to value informal care in economic evaluations of healthcare. Pharmacoeconomics 26(4), 269–280 (2008)PubMedCrossRef Koopmanschap, M.A., van Exel, N.J.A., van den Berg, B., Brouwer, W.B.: An overview of methods and applications to value informal care in economic evaluations of healthcare. Pharmacoeconomics 26(4), 269–280 (2008)PubMedCrossRef
43.
go back to reference Van Exel, J., Bobinac, A., Koopmanschap, M., Brouwer, W.: The invisible hands made visible: recognizing the value of informal care in healthcare decision-making. Expert Rev. Pharmacoecon. Outcomes Res. 8(6), 557–561 (2008)PubMedCrossRef Van Exel, J., Bobinac, A., Koopmanschap, M., Brouwer, W.: The invisible hands made visible: recognizing the value of informal care in healthcare decision-making. Expert Rev. Pharmacoecon. Outcomes Res. 8(6), 557–561 (2008)PubMedCrossRef
44.
go back to reference Cepparulo, A., Giuriato, L.: The residential healthcare for the elderly in Italy: some considerations for post-COVID-19 policies. Eur. J. Health Econ. 23(4), 671–685 (2022)PubMedCrossRef Cepparulo, A., Giuriato, L.: The residential healthcare for the elderly in Italy: some considerations for post-COVID-19 policies. Eur. J. Health Econ. 23(4), 671–685 (2022)PubMedCrossRef
45.
go back to reference Osborn, R., Moulds, D., Squires, D., Doty, M.M., Anderson, C.: International survey of older adults finds shortcomings in access, coordination, and patient-centered care. Health Aff. 33(12), 2247–2255 (2014)CrossRef Osborn, R., Moulds, D., Squires, D., Doty, M.M., Anderson, C.: International survey of older adults finds shortcomings in access, coordination, and patient-centered care. Health Aff. 33(12), 2247–2255 (2014)CrossRef
46.
go back to reference Mello, Jd.A., Macq, J., Van Durme, T., Cès, S., Spruytte, N., Van Audenhove, C., et al.: The determinants of informal caregivers’ burden in the care of frail older persons: a dynamic and role-related perspective. Aging Mental Health. 21(8), 838–843 (2017)PubMedCrossRef Mello, Jd.A., Macq, J., Van Durme, T., Cès, S., Spruytte, N., Van Audenhove, C., et al.: The determinants of informal caregivers’ burden in the care of frail older persons: a dynamic and role-related perspective. Aging Mental Health. 21(8), 838–843 (2017)PubMedCrossRef
47.
go back to reference Krol, M., Brouwer, W.: How to estimate productivity costs in economic evaluations. Pharmacoeconomics 32(4), 335–344 (2014)PubMedCrossRef Krol, M., Brouwer, W.: How to estimate productivity costs in economic evaluations. Pharmacoeconomics 32(4), 335–344 (2014)PubMedCrossRef
48.
go back to reference Tong T. Broadening the perspective of economic evaluation in health care - A case study in dementia care in the UK: University of Sheffield; 2017. Tong T. Broadening the perspective of economic evaluation in health care - A case study in dementia care in the UK: University of Sheffield; 2017.
49.
go back to reference Squires, H., Chilcott, J., Akehurst, R., Burr, J., Kelly, M.P.: A systematic literature review of the key challenges for developing the structure of public health economic models. Int. J. Public Health 61(3), 289–298 (2016)PubMedCrossRef Squires, H., Chilcott, J., Akehurst, R., Burr, J., Kelly, M.P.: A systematic literature review of the key challenges for developing the structure of public health economic models. Int. J. Public Health 61(3), 289–298 (2016)PubMedCrossRef
50.
go back to reference Sivan, M., Greenhalgh, T., Darbyshire, J.L., Mir, G., O’Connor, R.J., Dawes, H., et al.: LOng COvid Multidisciplinary consortium optimising treatments and servIces acrOss the NHS (Locomotion): protocol for a mixed-methods study in the UK. BMJ Open 12(5), e063505 (2022)PubMedCrossRef Sivan, M., Greenhalgh, T., Darbyshire, J.L., Mir, G., O’Connor, R.J., Dawes, H., et al.: LOng COvid Multidisciplinary consortium optimising treatments and servIces acrOss the NHS (Locomotion): protocol for a mixed-methods study in the UK. BMJ Open 12(5), e063505 (2022)PubMedCrossRef
51.
go back to reference European Burden of Disease Network. Burden of disease of COVID-19: Protocol for country studies. In: Technology ECiS, editor. 2020. European Burden of Disease Network. Burden of disease of COVID-19: Protocol for country studies. In: Technology ECiS, editor. 2020.
52.
go back to reference Wyper G, Assunção R, Colzani E, Grant I, Haagsma JA, Lagerweij G, et al. Burden of disease methods: a guide to calculate COVID-19 disability-adjusted life years. International Journal of Public Health. 2021:4. Wyper G, Assunção R, Colzani E, Grant I, Haagsma JA, Lagerweij G, et al. Burden of disease methods: a guide to calculate COVID-19 disability-adjusted life years. International Journal of Public Health. 2021:4.
53.
go back to reference Angeles, M.R., Wanni Arachchige Dona, S., Nguyen, H.D., Le, L.K.-D., Hensher, M.: Modelling the potential acute and post-acute burden of COVID-19 under the Australian border re-opening plan. BMC Public Health 22(1), 1–13 (2022)CrossRef Angeles, M.R., Wanni Arachchige Dona, S., Nguyen, H.D., Le, L.K.-D., Hensher, M.: Modelling the potential acute and post-acute burden of COVID-19 under the Australian border re-opening plan. BMC Public Health 22(1), 1–13 (2022)CrossRef
54.
go back to reference Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes: Oxford university press; 2015. Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the economic evaluation of health care programmes: Oxford university press; 2015.
55.
go back to reference Briggs A, Sculpher M, Claxton K. Decision modelling for health economic evaluation: Oup Oxford; 2006. Briggs A, Sculpher M, Claxton K. Decision modelling for health economic evaluation: Oup Oxford; 2006.
56.
go back to reference Philips Z, Ginnelly L, Sculpher M, Claxton K, Golder S, Riemsma R, et al. Review of guidelines for good practice in decision-analytic modelling in health technology assessment. 2004. Philips Z, Ginnelly L, Sculpher M, Claxton K, Golder S, Riemsma R, et al. Review of guidelines for good practice in decision-analytic modelling in health technology assessment. 2004.
57.
go back to reference Sivan, M., Parkin, A., Makower, S., Greenwood, D.C.: Post-COVID syndrome symptoms, functional disability, and clinical severity phenotypes in hospitalized and nonhospitalized individuals: A cross-sectional evaluation from a community COVID rehabilitation service. J. Med. Virol. 94(4), 1419–1427 (2022)PubMedCrossRef Sivan, M., Parkin, A., Makower, S., Greenwood, D.C.: Post-COVID syndrome symptoms, functional disability, and clinical severity phenotypes in hospitalized and nonhospitalized individuals: A cross-sectional evaluation from a community COVID rehabilitation service. J. Med. Virol. 94(4), 1419–1427 (2022)PubMedCrossRef
58.
go back to reference Straudi, S., Manfredini, F., Baroni, A., Milani, G., Fregna, G., Schincaglia, N., et al.: Construct validity and responsiveness of the COVID-19 Yorkshire rehabilitation scale (C19-YRS) in a cohort of Italian hospitalized COVID-19 Patients. Int. J. Environ. Res. Public Health 19(11), 6696 (2022)PubMedPubMedCentralCrossRef Straudi, S., Manfredini, F., Baroni, A., Milani, G., Fregna, G., Schincaglia, N., et al.: Construct validity and responsiveness of the COVID-19 Yorkshire rehabilitation scale (C19-YRS) in a cohort of Italian hospitalized COVID-19 Patients. Int. J. Environ. Res. Public Health 19(11), 6696 (2022)PubMedPubMedCentralCrossRef
59.
go back to reference Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., et al.: Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual. Life Res. 20(10), 1727–1736 (2011)PubMedPubMedCentralCrossRef Herdman, M., Gudex, C., Lloyd, A., Janssen, M., Kind, P., Parkin, D., et al.: Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L). Qual. Life Res. 20(10), 1727–1736 (2011)PubMedPubMedCentralCrossRef
60.
go back to reference Hernández Alava M, Pudney S, Wailoo A. Estimating the relationship between EQ-5D-5L and EQ-5D-3L: results from an English Population Study. In: York UoSa, editor. Policy Research Unit in Economic Evaluation of Health and Care Interventions2020. Hernández Alava M, Pudney S, Wailoo A. Estimating the relationship between EQ-5D-5L and EQ-5D-3L: results from an English Population Study. In: York UoSa, editor. Policy Research Unit in Economic Evaluation of Health and Care Interventions2020.
64.
go back to reference StataCorp. Stata Statistical Software: Release 17. In: College Station TSL, editor. 2019. StataCorp. Stata Statistical Software: Release 17. In: College Station TSL, editor. 2019.
66.
go back to reference Thompson, E.J., Williams, D.M., Walker, A.J., Mitchell, R.E., Niedzwiedz, C.L., Yang, T.C., et al.: Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nat. Commun. 13(1), 3528 (2022)PubMedPubMedCentralCrossRef Thompson, E.J., Williams, D.M., Walker, A.J., Mitchell, R.E., Niedzwiedz, C.L., Yang, T.C., et al.: Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records. Nat. Commun. 13(1), 3528 (2022)PubMedPubMedCentralCrossRef
67.
go back to reference Babnik, K., Staresinic, C., Lep, Ž: Some of the workforce face post COVID after the acute phase of the illness: the employer’s supportive role. Hum. Syst. Manag. 41(2), 257–275 (2022)CrossRef Babnik, K., Staresinic, C., Lep, Ž: Some of the workforce face post COVID after the acute phase of the illness: the employer’s supportive role. Hum. Syst. Manag. 41(2), 257–275 (2022)CrossRef
68.
go back to reference Kingdon, C.C., Bowman, E.W., Curran, H., Nacul, L., Lacerda, E.M.: Functional status and well-being in people with myalgic encephalomyelitis/chronic fatigue syndrome compared with people with multiple sclerosis and healthy controls. PharmacoEconomics-open. 2(4), 381–392 (2018)PubMedPubMedCentralCrossRef Kingdon, C.C., Bowman, E.W., Curran, H., Nacul, L., Lacerda, E.M.: Functional status and well-being in people with myalgic encephalomyelitis/chronic fatigue syndrome compared with people with multiple sclerosis and healthy controls. PharmacoEconomics-open. 2(4), 381–392 (2018)PubMedPubMedCentralCrossRef
69.
go back to reference Verrill, M., Wardley, A.M., Retzler, J., Smith, A.B., Bottomley, C., Ní Dhochartaigh, S., et al.: Health-related quality of life and work productivity in UK patients with HER2-positive breast cancer: a cross-sectional study evaluating the relationships between disease and treatment stage. Health Qual. Life Outcomes 18, 1–12 (2020)CrossRef Verrill, M., Wardley, A.M., Retzler, J., Smith, A.B., Bottomley, C., Ní Dhochartaigh, S., et al.: Health-related quality of life and work productivity in UK patients with HER2-positive breast cancer: a cross-sectional study evaluating the relationships between disease and treatment stage. Health Qual. Life Outcomes 18, 1–12 (2020)CrossRef
70.
go back to reference Collin SM, Crawley E, May MT, Sterne JA, Hollingworth W, Database UCMNO. The impact of CFS/ME on employment and productivity in the UK: a cross-sectional study based on the CFS/ME national outcomes database. BMC health services research. 2011; 11:1–8. Collin SM, Crawley E, May MT, Sterne JA, Hollingworth W, Database UCMNO. The impact of CFS/ME on employment and productivity in the UK: a cross-sectional study based on the CFS/ME national outcomes database. BMC health services research. 2011; 11:1–8.
71.
go back to reference Parsekar, K., Wilsher, S.H., Sweeting, A., Patel, A., Fordham, R.: Societal costs of chemotherapy in the UK: an incidence-based cost-of-illness model for early breast cancer. BMJ Open 11(1), e039412 (2021)PubMedPubMedCentralCrossRef Parsekar, K., Wilsher, S.H., Sweeting, A., Patel, A., Fordham, R.: Societal costs of chemotherapy in the UK: an incidence-based cost-of-illness model for early breast cancer. BMJ Open 11(1), e039412 (2021)PubMedPubMedCentralCrossRef
72.
go back to reference Cochrane, M., Mitchell, E., Hollingworth, W., Crawley, E., Trépel, D.: Cost-effectiveness of interventions for chronic fatigue syndrome or Myalgic encephalomyelitis: a systematic review of economic evaluations. Appl. Health Econ. Health Policy 19, 473–486 (2021)PubMedPubMedCentralCrossRef Cochrane, M., Mitchell, E., Hollingworth, W., Crawley, E., Trépel, D.: Cost-effectiveness of interventions for chronic fatigue syndrome or Myalgic encephalomyelitis: a systematic review of economic evaluations. Appl. Health Econ. Health Policy 19, 473–486 (2021)PubMedPubMedCentralCrossRef
73.
go back to reference Weatherly, H., Drummond, M., Claxton, K., Cookson, R., Ferguson, B., Godfrey, C., et al.: Methods for assessing the cost-effectiveness of public health interventions: key challenges and recommendations. Health Policy 93(2–3), 85–92 (2009)PubMedCrossRef Weatherly, H., Drummond, M., Claxton, K., Cookson, R., Ferguson, B., Godfrey, C., et al.: Methods for assessing the cost-effectiveness of public health interventions: key challenges and recommendations. Health Policy 93(2–3), 85–92 (2009)PubMedCrossRef
74.
go back to reference Kelly, M.P., McDaid, D., Ludbrook, A., Powell, J.: Economic appraisal of public health interventions. Health Development Agency, London (2005) Kelly, M.P., McDaid, D., Ludbrook, A., Powell, J.: Economic appraisal of public health interventions. Health Development Agency, London (2005)
75.
go back to reference Norheim, O.F., Baltussen, R., Johri, M., Chisholm, D., Nord, E., Brock, D., et al.: Guidance on priority setting in health care (GPS-Health): the inclusion of equity criteria not captured by cost-effectiveness analysis. Cost Effect Resource Allocation. 12(1), 18 (2014)CrossRef Norheim, O.F., Baltussen, R., Johri, M., Chisholm, D., Nord, E., Brock, D., et al.: Guidance on priority setting in health care (GPS-Health): the inclusion of equity criteria not captured by cost-effectiveness analysis. Cost Effect Resource Allocation. 12(1), 18 (2014)CrossRef
76.
go back to reference Subramanian, A., Nirantharakumar, K., Hughes, S., Myles, P., Williams, T., Gokhale, K.M., et al.: Symptoms and risk factors for long COVID in non-hospitalized adults. Nat. Med. 28(8), 1706–1714 (2022)PubMedPubMedCentralCrossRef Subramanian, A., Nirantharakumar, K., Hughes, S., Myles, P., Williams, T., Gokhale, K.M., et al.: Symptoms and risk factors for long COVID in non-hospitalized adults. Nat. Med. 28(8), 1706–1714 (2022)PubMedPubMedCentralCrossRef
77.
go back to reference Murali, M., Gumber, L., Jethwa, H., Ganesh, D., Hartmann-Boyce, J., Sood, H., et al.: Ethnic minority representation in UK COVID-19 trials: systematic review and meta-analysis. BMC Med. 21(1), 1–18 (2023)CrossRef Murali, M., Gumber, L., Jethwa, H., Ganesh, D., Hartmann-Boyce, J., Sood, H., et al.: Ethnic minority representation in UK COVID-19 trials: systematic review and meta-analysis. BMC Med. 21(1), 1–18 (2023)CrossRef
78.
go back to reference Mir, G., Salway, S., Kai, J., Karlsen, S., Bhopal, R., Ellison, G.T., et al.: Principles for research on ethnicity and health: the Leeds Consensus Statement. European J Public Health. 23(3), 504–510 (2013)CrossRef Mir, G., Salway, S., Kai, J., Karlsen, S., Bhopal, R., Ellison, G.T., et al.: Principles for research on ethnicity and health: the Leeds Consensus Statement. European J Public Health. 23(3), 504–510 (2013)CrossRef
79.
go back to reference Beck, A., Crain, A.L., Solberg, L.I., Unützer, J., Glasgow, R.E., Maciosek, M.V., et al.: Severity of depression and magnitude of productivity loss. Annals Family Med 9(4), 305–311 (2011)CrossRef Beck, A., Crain, A.L., Solberg, L.I., Unützer, J., Glasgow, R.E., Maciosek, M.V., et al.: Severity of depression and magnitude of productivity loss. Annals Family Med 9(4), 305–311 (2011)CrossRef
80.
go back to reference Chen, J., Taylor, B., Palmer, A.J., Kirk-Brown, A., van Dijk, P., Simpson, S., Jr., et al.: Estimating MS-related work productivity loss and factors associated with work productivity loss in a representative Australian sample of people with multiple sclerosis. Mult. Scler. J. 25(7), 994–1004 (2019)CrossRef Chen, J., Taylor, B., Palmer, A.J., Kirk-Brown, A., van Dijk, P., Simpson, S., Jr., et al.: Estimating MS-related work productivity loss and factors associated with work productivity loss in a representative Australian sample of people with multiple sclerosis. Mult. Scler. J. 25(7), 994–1004 (2019)CrossRef
81.
go back to reference Algamdi, M., Sadatsafavi, M., Fisher, J.H., Morisset, J., Johannson, K.A., Fell, C.D., et al.: Costs of workplace productivity loss in patients with fibrotic interstitial lung disease. Chest 156(5), 887–895 (2019)PubMedCrossRef Algamdi, M., Sadatsafavi, M., Fisher, J.H., Morisset, J., Johannson, K.A., Fell, C.D., et al.: Costs of workplace productivity loss in patients with fibrotic interstitial lung disease. Chest 156(5), 887–895 (2019)PubMedCrossRef
82.
go back to reference Sabes-Figuera, R., McCrone, P., Hurley, M., King, M., Donaldson, A.N., Ridsdale, L.: The hidden cost of chronic fatigue to patients and their families. BMC Health Serv. Res. 10(1), 1–7 (2010)CrossRef Sabes-Figuera, R., McCrone, P., Hurley, M., King, M., Donaldson, A.N., Ridsdale, L.: The hidden cost of chronic fatigue to patients and their families. BMC Health Serv. Res. 10(1), 1–7 (2010)CrossRef
83.
go back to reference Lin, J.M.S., Resch, S.C., Brimmer, D.J., Johnson, A., Kennedy, S., Burstein, N., et al.: The economic impact of chronic fatigue syndrome in Georgia: direct and indirect costs. Cost Effectiveness Resou Allocation 9(1), 1–12 (2011)CrossRef Lin, J.M.S., Resch, S.C., Brimmer, D.J., Johnson, A., Kennedy, S., Burstein, N., et al.: The economic impact of chronic fatigue syndrome in Georgia: direct and indirect costs. Cost Effectiveness Resou Allocation 9(1), 1–12 (2011)CrossRef
84.
go back to reference Close S, Marshall-Gradisnik S, Byrnes J, Smith P, Nghiem S, Staines D. The economic impacts of myalgic encephalomyelitis/chronic fatigue syndrome in an Australian cohort. Frontiers in Public Health. 2020: 420. Close S, Marshall-Gradisnik S, Byrnes J, Smith P, Nghiem S, Staines D. The economic impacts of myalgic encephalomyelitis/chronic fatigue syndrome in an Australian cohort. Frontiers in Public Health. 2020: 420.
Metadata
Title
Impact of Long COVID on productivity and informal caregiving
Authors
Joseph Kwon
Ruairidh Milne
Clare Rayner
Román Rocha Lawrence
Jordan Mullard
Ghazala Mir
Brendan Delaney
Manoj Sivan
Stavros Petrou
Publication date
26-12-2023
Publisher
Springer Berlin Heidelberg
Published in
The European Journal of Health Economics / Issue 7/2024
Print ISSN: 1618-7598
Electronic ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-023-01653-z

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