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Annals of Surgical Oncology
Published in:

18-12-2024 | Liver Resection | Hepatobiliary Tumors

Recurrent Colorectal Liver Metastases: Opportunities for Biology-Informed Surgery Beyond Initial Hepatectomy

Authors: Yifan Wang, MD, PhD, Timothy E. Newhook, MD

Published in: Annals of Surgical Oncology | Issue 3/2025

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Excerpt

In this issue of Annals of Surgical Oncology, Kobayashi et al. present the survival of 392 patients who developed intrahepatic recurrence after initial curative-intent hepatectomy for colorectal liver metastases (CLM) from 2006 to 2020 at a single high-volume institution in Japan.1 Patients who underwent repeat hepatectomy had a significantly longer survival compared with those who did not undergo resection (5-year overall survival [OS] from initial liver resection, 66.3% vs. 27.2%; p < 0.001). The authors identified three predictors of poor prognosis for patients with recurrent CLM: ≥4 recurrent tumors, tumor size ≥5 cm, and presence of extrahepatic disease. These three factors were consolidated to stratify recurrent CLM into resectable versus borderline resectable versus unresectable categories, each with distinct prognoses (5-year OS: 67.3% vs. 30.8% vs. 2.6%). …
Literature
1.
2.
Boyev A, Tzeng CWD, Maki H, et al. Local therapy improves survival for early recurrence after resection of colorectal liver metastases. Ann Surg Oncol. 2024;31(4):2547–56.CrossRefPubMed
3.
Allard MA, Adam R. Repeat hepatectomy for colorectal liver metastases. In: JN Vauthey, Y Kawaguchi, R Adam, editors. Colorectal Liver Metastasis. Springer International Publishing; 2022. p. 265–76.CrossRef
4.
Lillemoe HA, Kawaguchi Y, Passot G, et al. Surgical resection for recurrence after two-stage hepatectomy for colorectal liver metastases is feasible, is safe, and improves survival. J Gastrointest Surg. 2019;23(1):84–92.CrossRefPubMed
5.
Fromer MW, Scoggins CR, Egger ME, Philips P, McMasters KM, Ii Martin RCG. Preventing futile liver resection: a risk-based approach to surgical selection in major hepatectomy for colorectal cancer. Ann Surg Oncol. 2022;29(2):905–12.CrossRefPubMed
6.
Dijkstra M, Kuiper BI, Schulz HH, et al. Recurrent colorectal liver metastases: Upfront local treatment versus neoadjuvant systemic therapy followed by local treatment (COLLISION RELAPSE): study protocol of a phase III prospective randomized controlled trial. Cardiovasc Radiol. 2024;47(2):253–62.CrossRef
7.
Maddalena G, Pellatt AJ, Eluri M, et al. INTERCEPT Program of circulating tumor DNA (ctDNA) testing for minimal residual disease (MRD) in colorectal cancer (CRC): results from a prospective clinical cohort. J Clin Oncol. 2024;42(3 Suppl):27.CrossRef
8.
Nishioka Y, Chun YS, Overman MJ, et al. Effect of co-mutation of RAS and TP53 on postoperative ctDNA detection and early recurrence after hepatectomy for colorectal liver metastases. J Am Coll Surg. 2022;234(4):474–83.CrossRefPubMed
Metadata
Title
Recurrent Colorectal Liver Metastases: Opportunities for Biology-Informed Surgery Beyond Initial Hepatectomy
Authors
Yifan Wang, MD, PhD
Timothy E. Newhook, MD
Publication date
18-12-2024
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 3/2025
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-16722-7

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