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Open Access 06-09-2024 | Original Contribution

Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial

Authors: Martin Purpura, Ralf Jäger, Ashok Godavarthi, Dhananjaya Bhaskarachar, Grant M. Tinsley

Published in: European Journal of Nutrition

Abstract

Purpose

L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.

Methods

In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n = 27; 36.0 ± 5.1 years, 165.0 ± 6.9 cm, 70.6 ± 7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage^®, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.

Results

VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC_0 − 24 in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC_0 − 24 (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.

Conclusion

Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.

Trial Registration

Clinical Trials Registry - India (CTRI/2023/04/051789).

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Title: Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial
Authors: Martin Purpura
Ralf Jäger
Ashok Godavarthi
Dhananjaya Bhaskarachar
Grant M. Tinsley
Publication date: 06-09-2024
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-024-03487-8

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Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial

Abstract

Purpose

Methods

Results

Conclusion

Trial Registration

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Abstract

Purpose

Methods

Results

Conclusion

Trial Registration

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