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Annals of Surgical Oncology

Open Access 04-01-2025 | Liposarcoma | ASO Author Reflections

ASO Author Reflections: Does Perioperative Radiotherapy have the Potential to Improve Disease-Specific Survival in Patients with Retroperitoneal Liposarcoma?

Authors: Alexander Wilhelm, MD, Benjamin Wiesler, MD, Beat P. Müller, MD

Published in: Annals of Surgical Oncology

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Excerpt

The potential benefits of neoadjuvant radiotherapy in patients with localized retroperitoneal sarcoma who undergo surgery have been called into question by the randomized STRASS trial.1 However, a subgroup analysis of patients with retroperitoneal liposarcoma suggested a possible beneficial effect of neoadjuvant radiotherapy on local recurrence rate, which was supported by a pooled analysis of STRASS trial and off-trial (STREXIT) data.2 The purpose of this study was to evaluate whether this beneficial effect of perioperative radiotherapy in liposarcoma on local recurrence rates translates into an improvement in disease-specific survival. …
Literature
1.
Bonvalot S, Gronchi A, Le Péchoux C, et al. Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial. Lancet Oncol. 2020;21(10):1366–77.CrossRefPubMed
2.
Callegaro D, Raut CP, Ajayi T, et al. Preoperative radiotherapy in patients with primary retroperitoneal sarcoma: EORTC-62092 trial (STRASS) versus off-trial (STREXIT) results. Ann Surg. 2023;278(1):127–34.CrossRefPubMed
3.
Metadata
Title
ASO Author Reflections: Does Perioperative Radiotherapy have the Potential to Improve Disease-Specific Survival in Patients with Retroperitoneal Liposarcoma?
Authors
Alexander Wilhelm, MD
Benjamin Wiesler, MD
Beat P. Müller, MD
Publication date
04-01-2025
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-16830-4
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