Evaluation of Antidiabetic Activity of Combination of Trace Elements
Sanjiv Singh *
Department of Pharmacology, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh India
H. S. Chandel
Department of Pharmacology, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh India
Sujeet Kushwaha
Department of Pharmacology, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh India
Jitendar Malik
Department of Pharma Chemistry, LN College of Pharmacy, Bhopal, Madhya Pradesh india
*Author to whom correspondence should be addressed.
Abstract
Background: In order to compare the three combinations of trace elements for correction of hyperglycemia, hyperlipidaemia, glycogen content in liver and activities of some important carbohydrate metabolic enzymes in diabetes mellitus, the anti diabetic effect and acute oral toxicity of a combination of trace elements were assessed.
Material and Methods: The anti-diabetic activity of the combination of the trace elements was compared with various non diabetic groups and Streptozotocin induced diabetes groups for period of 30 days.
Results and Conclusion: The results of the anti-diabetic activity of the combination of trace elements the aspects of Cholesterol, Triglycerides, Lipid Peroxidation, Glutathione, Catalase, Glycogen, Glucose -6- phosphates, oxidative stress parameters in liver indicated that the increased anti-diabetic activity and the protective efficacy of pancreas injury for diabetes were observed. The strong antihyperglycemic and antihyperlipidemic effect observed in streptozotocin-induced diabetic rats justifies the use of these combined trace elements for the treatment of diabetes-related complications.
Keywords: Trace elements, lipid peroxidation, antihyperlipidemic, triglycerides