Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

Eda Karadag-Oncel; Ozcan Erel; Yasemin Ozsurekci; Dilek Yagci Caglayik; Ali Kaya; Mustafa Gokhan Gozel; Fusun Dilara Icagasioglu; Aynur Engin; Gulay Korukluoglu; Yavuz Uyar; Nazif Elaldi; Mehmet Ceyhan

doi:10.7883/yoken.67.22

Original Article

Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

Eda Karadag-Oncel, Ozcan Erel, Yasemin Ozsurekci, Dilek Yagci Caglayik, Ali Kaya, Mustafa Gokhan Gozel, Fusun Dilara Icagasioglu, Aynur Engin, Gulay Korukluoglu, Yavuz Uyar, Nazif Elaldi, Mehmet Ceyhan

Author information

Eda Karadag-Oncel
Department of Pediatrics, Pediatric Infectious Disease Unit, Faculty of Medicine, Hacettepe University
Ozcan Erel
Department of Biochemistry, Atatürk Training and Research Hospital
Yasemin Ozsurekci
Department of Pediatrics, Pediatric Infectious Disease Unit, Faculty of Medicine, Hacettepe University
Dilek Yagci Caglayik
Refik Saydam National Public Health Agency
Ali Kaya
Department of Pediatrics, Faculty of Medicine, Cumhuriyet University
Mustafa Gokhan Gozel
Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University
Fusun Dilara Icagasioglu
Department of Pediatrics, Faculty of Medicine, Cumhuriyet University
Aynur Engin
Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University
Gulay Korukluoglu
Refik Saydam National Public Health Agency
Yavuz Uyar
Refik Saydam National Public Health Agency
Nazif Elaldi
Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University
Mehmet Ceyhan
Department of Pediatrics, Pediatric Infectious Disease Unit, Faculty of Medicine, Hacettepe University

Keywords: Crimean-Congo hemorrhagic fever, total antioxidant capacity, total oxidant status, plasma total thiol

JOURNAL FREE ACCESS

2014 Volume 67 Issue 1 Pages 22-26

DOI https://doi.org/10.7883/yoken.67.22

Details

Abstract

In this study, we investigated the pro- and antioxidant status of patients with a pathogenesis of Crimean-Congo hemorrhagic fever (CCHF) in terms of their role in its pathogenesis. During the study period, 34 children and 41 adults were diagnosed with CCHF. The control group consisted of healthy age- and gender-matched children and adults. Serum levels of the total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and plasma total thiol (TTL) were evaluated and compared between groups. The difference in mean TAC values between CCHF patients and healthy controls was not statistically significant (P > 0.05). Mean TOS, OSI, and TTL values were significantly lower in CCHF patients than in healthy controls (P < 0.001). Comparisons between the 2 groups revealed that mean TOS and OSI values were significantly lower in adults with CCHF than in their healthy counterparts (P < 0.001). Similarly, mean TTL levels were lower in both children and adults with CCHF when compared separately with healthy controls (P < 0.05). There was no significant difference in the mean serum TTL levels between children and adults with CCHF (P > 0.05). Our results suggest that TTL may play a more important role in CCHF pathogenesis than the other parameters investigated. The mean TOS and OSI values were higher in the control group than in CCHF patients.

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