STUDIES ON A NOVEL ANTITUMOR ANTIBIOTIC, PHENAZINOMYCIN: TAXONOMY, FERMENTATION, ISOLATION, AND PHYSICO-CHEMICAL AND BIOLOGICAL CHARACTERISTICS

SATOSHI OMURA; SHIGERU EDA; SHINJI FUNAYAMA; KANKI KOMIYAMA; YOKO TAKAHASHI; H. BOYD WOODRUFF

doi:10.7164/antibiotics.42.1037

SATOSHI OMURA, SHIGERU EDA, SHINJI FUNAYAMA, KANKI KOMIYAMA, YOKO TAKAHASHI, H. BOYD WOODRUFF

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JOURNAL FREE ACCESS

1989 Volume 42 Issue 7 Pages 1037-1042

DOI https://doi.org/10.7164/antibiotics.42.1037

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Abstract

A new antibiotic, phenazinomycin (C₂₇H₃₂N₂O, MW 400), was isolated from the cultural mycelium of Streptomyces sp. WK-2057. This antibiotic possesses antibacterial activities against Gram-positive bacteria in vitro, direct cytotoxic activities against HeLa S₃, P388 and P388 doxorubicin-resistant cells in vitro and antitumor activities against experimental murine tumors in vivo.

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