LEPTOMYCINS A AND B, NEW ANTIFUNGAL ANTIBIOTICS I. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION

TETSUO HAMAMOTO; SHIGEMICHI GUNJI; HIROAKI TSUJI; TERUHIKO BEPPU

doi:10.7164/antibiotics.36.639

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

LEPTOMYCINS A AND B, NEW ANTIFUNGAL ANTIBIOTICS

I. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION

TETSUO HAMAMOTO, SHIGEMICHI GUNJI, HIROAKI TSUJI, TERUHIKO BEPPU

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JOURNAL FREE ACCESS

1983 Volume 36 Issue 6 Pages 639-645

DOI https://doi.org/10.7164/antibiotics.36.639

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Abstract

A strain of Streptomyces was found to produce new antifungal antibiotics. The active compounds were purified and separated into two substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C₃₂H₄₆O₆ and C₃₃H₄₈O₆ respectively, and physicochemical and biological properties of them are very similar to each other. Leptomycins A and B exhibit strong inhibitory activity against Schizosaccharomyces and Mucor.

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