Anemia is a basic disease associated with various serious pathological conditions. Thus, effectively screening or monitoring patients for anemia is a critical issue for the World Health Organization. The recently developed Astrim SU, is a portable, noninvasive monitoring device for hemoglobin. In the present study, we investigated the efficacy and validity of the device for measuring basic items including hemoglobin and screening for anemia. Our data demonstrated the usefulness and applicability of the device in diverse clinical circumstances.