Certain crystals cause synovial tissue inflammation and variability of inflammatory indicators like plasmatic prostaglandin E₂ (PGE₂), fibrinogen (PF) and synovial tissue PGE₂. We evaluated Helium-Neon Laser efficacy on PF, plasmatic PGE₂ and synovial PGE₂ and its ability to induce involution of anatomopathological (AP) lesions in induced granulomatose process, alone and combined with a meloxicam injection. Rats were assigned to five different treatment groups. 5 mW He-Ne Laser radiation (632.8 nm) and 8 J.cm² energy density were used in the treated groups. PF and plasmatic PGE₂ and synovial PGE₂ levels decreased in granulomatose arthritis groups treated with low level laser therapy (LLLT) or with a meloxicam injection or a combination of both therapies; the differences being statistically significant (p<0.01), as compared with the non-treated control group. In the combination therapy group, involution of granulomatose inflammation was observed. We conclude that He-Ne laser treatment or meloxicam administration after experimentally induced inflammation, normalizes plasmatic PGE₂ and fibrinogen levels, but produces similar histological lesions as non-treated controls.