Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients

Takashi Motomura; Maki Okamoto; Tetsuhiro Kitamura; Hiroyasu Yamamoto; Michio Otsuki; Nobuyuki Asanuma; Miki Takagi; Shogo Kurebayashi; Kunihiko Hashimoto; Satoru Sumitani; Hiroshi Saito; Haruhiko Kouhara; Kazumasa Nshii; Makoto Nakao; Masafumi Koga; Bunzo Sato; Yasuhiko Morimoto; Soji Kasayama

doi:10.5551/jat.992

Original Articles

Effects of Pitavastatin on Serum Lipids and High Sensitivity C-Reactive Protein in Type 2 Diabetic Patients

Takashi Motomura, Maki Okamoto, Tetsuhiro Kitamura, Hiroyasu Yamamoto, Michio Otsuki, Nobuyuki Asanuma, Miki Takagi, Shogo Kurebayashi, Kunihiko Hashimoto, Satoru Sumitani, Hiroshi Saito, Haruhiko Kouhara, Kazumasa Nshii, Makoto Nakao, Masafumi Koga, Bunzo Sato, Yasuhiko Morimoto, Soji Kasayama

Author information

Takashi Motomura
Department of Medicine, NTT West Osaka Hospital
Maki Okamoto
Department of Medicine, Nissay Hospital
Tetsuhiro Kitamura
Department of Medicine, Nissay Hospital
Department of Medicine, Osaka University Graduate School of Medicine
Hiroyasu Yamamoto
Department of Medicine, NTT West Osaka Hospital
Michio Otsuki
Department of Medicine, Osaka University Graduate School of Medicine
Nobuyuki Asanuma
Department of Medicine, Osaka University Graduate School of Medicine
Miki Takagi
Department of Medicine, North Osaka Police Hospital
Shogo Kurebayashi
Department of Medicine, Nishinomiya Municipal Hospital
Kunihiko Hashimoto
Department of Medicine, Aizenbashi Hospital
Satoru Sumitani
Department of Medicine, Nissay Hospital
Hiroshi Saito
Department of Medicine, Kinki Central Hospital
Haruhiko Kouhara
Department of Medicine, Osaka University Graduate School of Medicine
Kazumasa Nshii
Department of Medicine, Osaka Hospital
Makoto Nakao
Nakao Naika Clinic
Masafumi Koga
Department of Medicine, Kinki Central Hospital
Bunzo Sato
Department of Medicine, Nissay Hospital
Yasuhiko Morimoto
Department of Medicine, Aizenbashi Hospital
Soji Kasayama
Department of Medicine, Nissay Hospital
Department of Medicine, Osaka University Graduate School of Medicine

Keywords: Statin, Pitavastatin, C-reactive protein, Diabetes mellitus, Inflammation

JOURNAL OPEN ACCESS

2009 Volume 16 Issue 5 Pages 546-552

DOI https://doi.org/10.5551/jat.992

View "Advance Publication" version (September 3, 2009).

Details

Abstract

Aim: Previous studies have been inconsistent results about the effects of statins on serum triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and high sensitivity C-reactive protein (hsCRP) levels. We therefore investigated the effects of pitavastatin on serum lipid profiles and hsCRP levels in patients with type 2 diabetes mellitus.
Methods: The study population was 65 Japanese type 2 diabetic patients who had been administered 2 mg daily of pitavastatin and completed a 6-month follow-up. Serum lipids and hsCRP were measured before and after treatment for 1, 3, and 6 months.
Results: Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and TG had significantly reduced after 1 month and remained reduced for 6 months, while HDL-C levels had significantly increased after 1 month and remained at the higher level for 6 months. Baseline median levels of hsCRP were 0.49 mg/L and showed a significant reduction to 0.37 mg/L at 6 months' treatment (p<0.001). Six-month changes in hsCRP levels were not associated with those in TC, LDL-C, HDL-C or TG.
Conclusion: Pitavastatin improved serum lipid profiles and reduced serum hsCRP levels in type 2 diabetic patients with relatively low inflammation. The effect on hsCRP was not related to the effects on serum lipid profiles.

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