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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2012; 22(02): 98-105
DOI: 10.4103/0971-3026.101080
Neuroradiology

Pictorial essay: Acute neurological complications in children with acute lymphoblastic leukemia

Seema A Kembhavi
Department of Radiodiagnosis, Tata Memorial Centre, Tata Memorial Hospital, Parel, Mumbai, India
,
Snehal Somvanshi
Department of Radiodiagnosis, Tata Memorial Centre, Tata Memorial Hospital, Parel, Mumbai, India
,
Shripad Banavali
Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Parel, Mumbai, India
,
Purna Kurkure
Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Parel, Mumbai, India
,
Brijesh Arora
Department of Medical Oncology, Tata Memorial Centre, Tata Memorial Hospital, Parel, Mumbai, India
› Author Affiliations Financial support and sponsorship Nil.
› Further Information
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Abstract

Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy with high cure rates due to recent advances in central nervous system (CNS) prophylaxis. The disease per se, as well as the prophylactic therapy, predisposes the child to complications such as cerebrovascular events, infections, drug toxicities, etc. The purpose of this study is to highlight the pathophysiology and the imaging features (with appropriate examples) of these complications and to propose a diagnostic algorithm based on MRI. Interpreting these scans in the light of clinical inputs very often helps the radiologist reach an appropriate diagnosis and help treatment and management.

Keywords

ALL - neurological complications - methotrexate induced leucoencephalopathy - PRES - immunocompromised patient


Publication History

Article published online:
30 July 2021

© 2012. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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