Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy

Mariko Tsuda; Yasuhiro Nakashima; Motohiko Ikeda; Shingo Shimada; Masatoshi Nomura; Takamitsu Matsushima; Shunsuke Takahashi; Shinichi Aishima; Yoshinao Oda; Motoaki Shiratsuchi; Ryoichi Takayanagi

doi:10.3960/jslrt.55.39

Case Study

Intravascular Large B-Cell Lymphoma Complicated by Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis that was Successfully Treated with Rituximab-Containing Chemotherapy

Mariko Tsuda, Yasuhiro Nakashima, Motohiko Ikeda, Shingo Shimada, Masatoshi Nomura, Takamitsu Matsushima, Shunsuke Takahashi, Shinichi Aishima, Yoshinao Oda, Motoaki Shiratsuchi, Ryoichi Takayanagi

Author information

Mariko Tsuda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Yasuhiro Nakashima
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Motohiko Ikeda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Shingo Shimada
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Masatoshi Nomura
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Takamitsu Matsushima
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Shunsuke Takahashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
Shinichi Aishima
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
Yoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University
Motoaki Shiratsuchi
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Ryoichi Takayanagi
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University

Keywords: intravascular large B-cell lymphoma, anti-neutrophil cytoplasmic antibody-associated vasculitis, rituximab

JOURNAL FREE ACCESS

2015 Volume 55 Issue 1 Pages 39-43

DOI https://doi.org/10.3960/jslrt.55.39

Details

Abstract

A 64-year-old woman had suffered from painful livedo reticularis for 2 years and was referred to us due to fever, anasarca and paresthesia of the lower limbs. Serum proteinase-3-anti-neutrophil cytoplasmic antibody (ANCA) was positive. Abnormal lymphocytes were found in the cerebrospinal fluid and bone marrow. Skin biopsy revealed large atypical lymphoid cells with CD20 positivity lodged in the small vessels and neutrophilic infiltration into the arterial vascular wall with fibrinoid degeneration. A diagnosis of intravascular large B-cell lymphoma complicated by ANCA-associated vasculitis was made, and rituximab-containing chemotherapy followed by prednisolone was quite effective for both lymphoma and ANCA-associated vasculitis.

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