Melatonin as a stabilizer of mitochondrial function: role in diseases and aging

Authors

CRISTINA CARRASCO
ANA B. RODRIGUEZ
JOSE A. PARIENTE

DOI

10.3906/biy-1504-26

Abstract

It is now almost 60 years since the discovery of melatonin and new physiological functions of the indole continuously appear in the most recent studies worldwide. Experimental evidence emphasizes its importance as a stabilizer of the mitochondrial bioenergetics, which could be related to the prevention of development of aging and several diseases. In the next years, conscientious investigation about this topic should be undertaken by scientists of different research areas to achieve a better understanding of the molecular mechanisms implied. This will ultimately allow the development and clinical application of efficacious treatments.

Keywords

Melatonin, mitochondria, diseases, aging, Alzheimer and Parkinson diseases

First Page

822

Last Page

831

Recommended Citation

CARRASCO, CRISTINA; RODRIGUEZ, ANA B.; and PARIENTE, JOSE A. (2015) "Melatonin as a stabilizer of mitochondrial function: role in diseases and aging," Turkish Journal of Biology: Vol. 39: No. 6, Article 3. https://doi.org/10.3906/biy-1504-26
Available at: https://journals.tubitak.gov.tr/biology/vol39/iss6/3