The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model
DOI:
https://doi.org/10.3109/17453674.2011.570677Abstract
Background and purpose There is some clinical evidence that fracture healing is impaired in multiply injured patients. Nothing is known, however, about the effects of various types of injuries and their contribution to a possible disturbance of the fracture-healing process. We investigated the effect of a thoracic trauma and an additional soft-tissue trauma on fracture healing in a rat tibia model. Methods 3 groups of rats were operated: group A with a simple fracture of the tibia and fibula, group B with a fracture and an additional thoracic trauma, and group C with a fracture, thoracic trauma, and an additional soft-tissue trauma. The fracture and the soft-tissue injury were produced by a special guillotine-like device and the thoracic trauma by a blast wave generator. After one day, the serum level of IL-6 was quantified, and at the end of the study (28 days) the mechanical properties and the callus volume of the healed tibia were determined. Results Increasing the severity of the injury caused IL-6 levels to more than double 1 day after injury. It halved the load to failure in mechanical tests and led to reduced callus volume after 28 days of healing. Interpretation Fracture healing is impaired when additional thoracic trauma and soft tissue trauma occurs.Downloads
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Published
2011-04-01
How to Cite
Claes, L., Ignatius, A., Lechner, R., Gebhard, F., Kraus, M., Baumgärtel, S., Recknagel, S., & Krischak, G. D. (2011). The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model. Acta Orthopaedica, 82(2), 223–227. https://doi.org/10.3109/17453674.2011.570677
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LicenseActa Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.