GUIDELINES   Free access

Giornale Italiano di Dermatologia e Venereologia 2018 December;153(6):747-62

DOI: 10.23736/S0392-0488.18.06093-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

Cutaneous squamous cell carcinoma. Italian Guidelines by SIDeMaST adapted to and updating EADO/EDF/EORTC guidelines

Ketty PERIS ¹ ✉, Mauro ALAIBAC ², Giuseppe ARGENZIANO ³, Alessandro DI STEFANI ¹, Maria C. FARGNOLI ⁴, Pasquale FRASCIONE ⁵, Giulio GUALDI ⁶, Caterina LONGO ^{7, 8}, Elvira MOSCARELLA ³, Luigi NALDI ⁹, Giovanni PELLACANI ⁸, Nicola PIMPINELLI ¹⁰, Pietro QUAGLINO ¹¹, Marzia SALGARELLO ¹², Pietro SOLLENA ¹, Vincenzo VALENTINI ¹³, Iris ZALAUDEK ¹⁴, Pier Giacomo CALZAVARA-PINTON ⁶ on behalf of the Italian Group of Dermato-Oncology (GIDO) of SIDeMaST

¹ Department of Dermatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Sacred Heart Catholic University, Rome, Italy; ² Department of Dermatology, University of Padua, Padua, Italy; ³ Dermatology Unit, University Luigi Vanvitelli, Naples, Italy; ⁴ Department of Dermatology, University of L’Aquila, L’Aquila, Italy; ⁵ Department of Dermatology, Oncology and Prevention, Istituto Dermatologico San Gallicano, IFO, Rome, Italy; ⁶ Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy; ⁷ Department of Dermatology and Skin Cancer, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy; ⁸ Department of Dermatology, University of Modena and Reggio Emilia, Reggio Emilia, Italy; ⁹ Department of Dermatology, AULSS8 Berica, San Bortolo Hospital, Vicenza, Italy; ¹⁰ Section of Dermatology, Department of Surgery and Translational Medicine, Univeristy of Florence, P. Palagi Hospital, Florence, Italy; ¹¹ Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; ¹² Department of Plastic Surgery, Sacred Heart Catholic University, Rome, Italy; ¹³ Unit of Oncological Sciences and Hematology, Sacred Heart Catholic University, Rome, Italy; ¹⁴ Department of Surgery and Translational Medicine, University of Trieste, Trieste, Italy

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, accounting for 20% of all cutaneous malignancies, and has an increasing incidence in the elderly as well as in the younger population. Although most cSCC is treated with simple therapeutic procedures, advanced cSCC can lead a significant risk for morbidity, negative impact on quality of life, and death. Proper management includes distinguishing between high-risk and low-risk lesions and determining treatment accordingly. A collaboration of multidisciplinary Italian experts has given birth to these recommendations on cSCC diagnosis and management, based on a critical review of the literature, existing European (EADO-EDF-EORTC) guidelines and the expert’s experience. Topics covered include diagnostic path and histopathologic assessment, tumor staging, surgical and nonsurgical procedures, follow-up and management of localized and advanced disease.

KEY WORDS: Guidelines - Carcinoma, squamous cell - Diagnosis - Disease treatment