Hemijska industrija 2016 Volume 70, Issue 2, Pages: 113-122
https://doi.org/10.2298/HEMIND141229017N
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Edible mycorrhizal species Lactarius controversus Pers. 1800 as a source of antioxidant and cytotoxic agents
Novaković Aleksandra R. (Institute of Food Technology, Novi Sad)
Karaman Maja A. (Faculty of Sciences, Department of Biology and Ecology, Novi Sad)
Milovanović Ivan Lj. (Institute of Food Technology, Novi Sad)
Belović Miona M. (Institute of Food Technology, Novi Sad)
Rašeta Milena J. (Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad)
Radusin Tanja I. (Institute of Food Technology, Novi Sad)
Ilić Nebojša M. (Institute of Food Technology, Novi Sad)
The aim of this work was to study chemical profile and antioxidant and
cytotoxic activities of ethanol and water extracts of Lactarius controversus
(Pers.) 1800 mushroom species growing in eastern Serbia. The chemical
characterization of phenolic compounds performed by HPLC-MS/MS demonstrated
the presence of quinic acid among others. Determination of antioxidant
activity, including radical scavenging effects on DPPH•, NO•, OH• and SOA
radicals and ferric reducing ability was investigated. The highest DPPH
radical scavenging effect was obtained for water extract (LcAq) while ethanol
extract (LcEtOH) demonstrated the highest FRAP activity. Hexane extract
applied in antibacterial assay against three pathogenic strains demonstrated
antibacterial effect only against S. aureus ATCC25922. Anti-proliferative
properties against estrogen dependent MCF 7 breast cancer cell lines using
MTT showed higher activity for ethanolic extract.
Keywords: Lactarius controversus, phenolic compounds, quinic acid, antioxidants, cytotoxic agents
Projekat Ministarstva
nauke Republike Srbije, br. III 46001 i br. 172058