Medicinski pregled 2014 Volume 67, Issue 1-2, Pages: 49-54
https://doi.org/10.2298/MPNS1402049J
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Correlation between metabolic controls and changes in retina in patients having diabetes
Janićijević-Petrović Mirjana A. (Clinical Centre of Kragujevac, Department of Ophthalmology, Kragujevac)
Veljković Biljana (Health Centre for Protection of Workers, Kragujevac)
Janićijević Katarina (Faculty of Medical Sciences, Kragujevac)
Šarenac-Vulović Tatjana (Clinical Centre of Kragujevac, Department of Ophthalmology, Kragujevac)
Introduction. Diabetes mellitus is as old as the human race. Retinopathy,
being one of complications of diabetes mellitus, is the most common cause of
blindness. This study was aimed at analyzing the correlation between
retinopathy and duration of disease, metabolic control, and obesity. Material
and Methods. The study sample consisted of 135 patients divided into the
experimental group of 90 patients with retinopathy and the control group of
45 patients without retinopathy. The patients were examined according to
standard protocols: anamneses, endocrinology, ophthalmology exams,
biochemical analyses, and anthropometric measurements. Results. The average
age of patients was 60.13 ± 9.29 in the experimental group, while it was
57.55 ± 4.85 in the control group. The average duration of disease was 11.71
± 5.8 and 14.40 ± 7.68 in the control group experimental group, respectively.
The following statistically essential differences between the control and
experimental group were found: in duration of disease (11.71 ± 5.85; 14.40 ±
7.68; r = 0.000), in glycemia (7.02 ± 2.20; 8.34 ± 3.18; p = 0.000), in
glycosylated hemoglobin A1C (HbA1C) (7.16 ± 1.37; 8.22 ± 2.05; r = 0.000), in
triglycerides (1.92 ± 0.72; 2.63 ± 1.60; r = 0.001), and in body mass index
(23.94 ± 2.65; 27.66 ± 15.13; r = 0.000). Conclusion. There is a positive
correlation between duration of disease, glycosylated hemoglobin A1C,
triglycerides, body mass index - obesity and retinopathy. A significant
statistical correlation among those parameters has been found in patients
with diabetic retinopathy.
Keywords: Diabetes Mellitus, Metabolic Diseases, Diabetic Retinopathy, Hemoglobin A, Glycosylated, Triglycerides, Body Mass Index, Middle Aged, Aged