doiSerbia

Squamous cell carcinoma in mature cystic teratoma of the ovary

Amidžić Jelena (Clinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad + Faculty of Medicine, Department of Histology and Embriology, Novi Sad)
Đolai Matilda (Clinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad + Faculty of Medicine, Department of Histology and Embriology, Novi Sad)
Mocko-Kaćanski Mihaela (Clinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad + Faculty of Medicine, Department of Histology and Embriology, Novi Sad)
Gluhović Aleksandar (Clinical Center of Vojvodina, Emergency Room, Novi Sad)
Ilić Jelena (Faculty of Medicine, Department of Histology and Embriology, Novi Sad)
Božanić Snežana (Clinical Center of Vojvodina, Emergency Room, Novi Sad + Faculty of Medicine, Department of Pathology, Novi Sad)

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

Keywords: Carcinoma, Squamous Cell, Teratoma, Ovarian Cysts + pathology, Ovarian Neoplasms + pathology, Cell Transformation, Neoplastic, Female, Aged, 80 and over