Clivus Metastasis From Gastric Signet Ring Cell Carcinoma After a 10-Year Disease-Free Interval —Case Report—

Masamichi FUKUSHIMA; Yoichi KATAYAMA; Yutaka SHIGEMORI; Hiroshi MIYAKE; Teruyasu HIRAYAMA; Akio KOTANI

doi:10.2176/nmc.52.751

Case Reports

Clivus Metastasis From Gastric Signet Ring Cell Carcinoma After a 10-Year Disease-Free Interval

—Case Report—

Masamichi FUKUSHIMA, Yoichi KATAYAMA, Yutaka SHIGEMORI, Hiroshi MIYAKE, Teruyasu HIRAYAMA, Akio KOTANI

Author information

Keywords: clivus metastasis, signet ring cell carcinoma, abducens nerve palsy, late recurrence, tumor dormancy

JOURNAL OPEN ACCESS

2012 Volume 52 Issue 10 Pages 751-753

DOI https://doi.org/10.2176/nmc.52.751

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Abstract

A 64-year-old male presented with an extremely unusual case of solitary clivus metastasis from gastric cancer manifesting as mild headache and diplopia 10 years after radical excision of the primary tumor. The patient underwent surgical resection using an endoscopic transsphenoidal approach. Histological examination revealed typical signet ring cell carcinoma (SRC) which was identical to that of the previous gastric cancer. Why the late recurrence occurred such a long time after the first surgery and how it spread to the clivus remain unclear. The characteristics of SRC and the process of “tumor dormancy” may have been involved in the mechanism underlying late metastasis.

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