Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury

Takahiro Uchida; Takashi Oda; Dan Inoue; Shuhei Komatsu; Tadasu Kojima; Tomohiro Tomiyasu; Noriko Yoshikawa; Muneharu Yamada

doi:10.2169/internalmedicine.7809-21

CASE REPORTS

Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury

Takahiro Uchida, Takashi Oda, Dan Inoue, Shuhei Komatsu, Tadasu Kojima, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada

Author information

Takahiro Uchida
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Takashi Oda
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Dan Inoue
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Shuhei Komatsu
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Tadasu Kojima
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Tomohiro Tomiyasu
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Noriko Yoshikawa
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan
Muneharu Yamada
Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Japan

Keywords: acute kidney injury, Capnocytophaga, Thomsen-Friedenreich antigen, thrombotic microangiopathy

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 7 Pages 1021-1026

DOI https://doi.org/10.2169/internalmedicine.7809-21

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Abstract

Infections with neuraminidase-producing bacteria can lead to acute kidney injury (AKI). We herein report a 74-year-old woman who developed AKI in the course of Capnocytophaga infection, a neuraminidase-producing bacterium. A renal biopsy showed tubulointerstitial injury accompanied by specific binding of fluorescence-conjugated peanut lectin to the tubular epithelial cells, suggesting exposure of Thomsen-Friedenreich antigen (T-antigen) on the tubules. Although AKI is often observed in patients infected with Capnocytophaga, little is known about its etiology and associated pathology. This case suggests that tubulointerstitial injury caused by neuraminidase production and resultant T-antigen exposure is a mechanism of Capnocytophaga infection-induced AKI.

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