Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis

Jun Kikuchi; Yuko Kaneko; Hidenori Kasahara; Katsura Emoto; Akiharu Kubo; Shinichiro Okamoto; Tsutomu Takeuchi

doi:10.2169/internalmedicine.55.6943

CASE REPORTS

Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis

Jun Kikuchi, Yuko Kaneko, Hidenori Kasahara, Katsura Emoto, Akiharu Kubo, Shinichiro Okamoto, Tsutomu Takeuchi

Author information

Keywords: rheumatoid arthritis, intravascular lymphoma, methotrexate, spontaneous regression

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 12 Pages 1661-1665

DOI https://doi.org/10.2169/internalmedicine.55.6943

Details

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

Corresponding author

Register with J-STAGE for free!