Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease

Masaki Ohyagi; Takuya Ohkubo; Yousuke Yagi; Satoru Ishibashi; Junko Akiyama; Masakazu Nagahori; Mamoru Watanabe; Takanori Yokota; Hidehiro Mizusawa

doi:10.2169/internalmedicine.52.8452

CASE REPORTS

Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease

Masaki Ohyagi, Takuya Ohkubo, Yousuke Yagi, Satoru Ishibashi, Junko Akiyama, Masakazu Nagahori, Mamoru Watanabe, Takanori Yokota, Hidehiro Mizusawa

Author information

Masaki Ohyagi
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
Takuya Ohkubo
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
Yousuke Yagi
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
Satoru Ishibashi
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
Junko Akiyama
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
Masakazu Nagahori
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
Mamoru Watanabe
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Japan
Takanori Yokota
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
Hidehiro Mizusawa
Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan

Keywords: chronic inflammatory demyelinating polyradiculoneuropathy, Crohn's disease, inflammatory bowel disease, extraintestinal manifestations, neurological complications, humoral factors

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 1 Pages 125-128

DOI https://doi.org/10.2169/internalmedicine.52.8452

Details

Abstract

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract that is frequently accompanied by systemic complications. Neuropathologies have not been well investigated as extraintestinal manifestations of CD. We herein report the case of a 36-year-old man with CD who presented with progressive weakness and numbness. A neurological examination and the results of a nerve conduction study and a sural nerve biopsy led to a diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Plasma exchanges were initially effective; however, the effects gradually declined starting 10 days after the plasma exchange (PE). These results suggest that humoral factors may play an important role in CIDP associated with CD.

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