Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Elderly Patients with Rheumatoid Arthritis Associated with Infections: Report of Two Cases

Eiichi FURUTA; Masayuki YASUDA; Kazunori YOSHIOKA; Tetsuro ISAYAMA; Masashi NOBUNAGA

doi:10.2169/internalmedicine.35.478

Eiichi FURUTA, Masayuki YASUDA, Kazunori YOSHIOKA, Tetsuro ISAYAMA, Masashi NOBUNAGA

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Keywords: hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone, rheumatoid arthritis, herpes zoster, Staphylococcus simulans, septicemia

JOURNAL FREE ACCESS

1996 Volume 35 Issue 6 Pages 478-481

DOI https://doi.org/10.2169/internalmedicine.35.478

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Abstract

Two rheumatoid arthritis (RA) patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) during the course of infection are herein reported. One patient developed SIADH during the course of a localized cutaneous herpes zoster infection while the other developed SIADH in conjunction with Staphylococcus simulans septicemia. We consider that the development of SIADH was strongly associated with superimposed infections in the underlying RA. This is the first report discussing the association of SIADH and infections in RA patients in which SIADH is diagnosed by measurement of plasma ADH.
(Internal Medicine 35: 478-481, 1996)

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