A Case of Selective IgM Deficiency: Isotype-specific Suppressor T Lymphocytes

Sho MATSUSHITA; Takatoshi INOUE; Hideo OKUBO

doi:10.2169/internalmedicine1962.23.149

Sho MATSUSHITA, Takatoshi INOUE, Hideo OKUBO

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Keywords: Isotype-specific suppressor factor, Cell-surface immunoglobulins, Immunodeficiency, Leiomyoma, Selective IgM deficiency

JOURNAL FREE ACCESS

1984 Volume 23 Issue 2 Pages 149-151

DOI https://doi.org/10.2169/internalmedicine1962.23.149

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Abstract

A case of selective IgM deficiency with giant leiomyoma of the stomach in a 66-year-old male is reported. Peripheral blood mononuclear cells from the patient synthesized only a small amount of IgM in the presence of pokeweed mitogen (PWM) in vitro. Co-culture of counterpart lymphocytes from the patient and a disease-free individual revealed that increased activity of IgM-specific suppressor T lymphocytes led to a IgM deficiency in this case.

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