Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B Cell Lymphoma and Acute Myeloid Leukemia

Junichi Miyatake; Hiroaki Inoue; Kentarou Serizawa; Yasuyoshi Morita; JL Espinoza; Hirokazu Tanaka; Takahiro Shimada; Yoichi Tatsumi; Takashi Ashida; Itaru Matsumura

doi:10.2169/internalmedicine.9668-17

CASE REPORTS

Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B Cell Lymphoma and Acute Myeloid Leukemia

Junichi Miyatake, Hiroaki Inoue, Kentarou Serizawa, Yasuyoshi Morita, JL Espinoza, Hirokazu Tanaka, Takahiro Shimada, Yoichi Tatsumi, Takashi Ashida, Itaru Matsumura

Author information

Junichi Miyatake
Department of Hematology, Sakai Hospital Kindai University Faculty of Medicine, Japan
Hiroaki Inoue
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Kentarou Serizawa
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Yasuyoshi Morita
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
JL Espinoza
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Hirokazu Tanaka
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Takahiro Shimada
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Yoichi Tatsumi
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Takashi Ashida
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
Itaru Matsumura
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan

Keywords: mycosis fungoides, diffuse large B-cell lymphoma, acute myelomonocytic leukemia, TET2

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 10 Pages 1445-1453

DOI https://doi.org/10.2169/internalmedicine.9668-17

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Abstract

Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed. Further clinical, experimental and genetic studies are needed to elucidate possible physiopathogenic associations among the three concurrent malignancies occurring in the cases presented here.

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