Diffuse Parenchymal Pulmonary Amyloidosis Showing an Objective Response to Bortezomib-based Chemotherapy

Hisao Higo; Keiichi Fujiwara; Hiromi Watanabe; Go Makimoto; Nobuhisa Kameyama; Mizuho Matsushita; Kammei Rai; Ken Sato; Tomoko Inomata; Kazutaka Sunami; Takuo Shibayama

doi:10.2169/internalmedicine.53.1728

CASE REPORTS

Diffuse Parenchymal Pulmonary Amyloidosis Showing an Objective Response to Bortezomib-based Chemotherapy

Hisao Higo, Keiichi Fujiwara, Hiromi Watanabe, Go Makimoto, Nobuhisa Kameyama, Mizuho Matsushita, Kammei Rai, Ken Sato, Tomoko Inomata, Kazutaka Sunami, Takuo Shibayama

Author information

Hisao Higo
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Keiichi Fujiwara
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Hiromi Watanabe
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Go Makimoto
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Nobuhisa Kameyama
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Mizuho Matsushita
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Kammei Rai
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Ken Sato
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan
Tomoko Inomata
Department of Hematology, National Hospital Organization Okayama Medical Center, Japan
Kazutaka Sunami
Department of Hematology, National Hospital Organization Okayama Medical Center, Japan
Takuo Shibayama
Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Japan

Keywords: diffuse parenchymal pulmonary amyloidosis, multiple myeloma, ground glass attenuation, bortezomib

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 16 Pages 1809-1812

DOI https://doi.org/10.2169/internalmedicine.53.1728

Details

Abstract

A 77-year-old woman was admitted because of bilateral hand numbness and dyspnea on exertion. Her serum IgG was increased, and a bone marrow aspiration analysis supported a diagnosis of multiple myeloma. Additionally, computed tomography scans of the chest showed bilateral ground glass attenuations, linear opacities, and consolidations. Transbronchial lung biopsy revealed Congo Red-positive amorphous eosinophilic deposits. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by multiple myeloma. Following combination chemotherapy including bortezomib, her serum monoclonal protein levels were normalized, and pulmonary function and oxygenation improved.

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