Mixed-type Multicentric Castleman's Disease Developing during a 17-year Follow-up of Sarcoidosis

Nobuyasu Awano; Minoru Inomata; Keisuke Kondoh; Kohta Satake; Hiroyuki Kamiya; Atsuko Moriya; Tsunehiro Ando; Toshio Kumasaka; Tamiko Takemura; Kengo Takeuchi; Soichiro Ikushima

doi:10.2169/internalmedicine.51.8120

CASE REPORTS

Mixed-type Multicentric Castleman's Disease Developing during a 17-year Follow-up of Sarcoidosis

Nobuyasu Awano, Minoru Inomata, Keisuke Kondoh, Kohta Satake, Hiroyuki Kamiya, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Kengo Takeuchi, Soichiro Ikushima

Author information

Nobuyasu Awano
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Minoru Inomata
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Keisuke Kondoh
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Kohta Satake
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Hiroyuki Kamiya
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Atsuko Moriya
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Tsunehiro Ando
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan
Toshio Kumasaka
Department of Pathology, Japanese Red Cross Medical Center, Japan
Tamiko Takemura
Department of Pathology, Japanese Red Cross Medical Center, Japan
Kengo Takeuchi
Department of Pathology, the Cancer Institute Hospital of JFCR, Japan
Soichiro Ikushima
Department of Respiratory Medicine, Japanese Red Cross Medical Center, Japan

Keywords: sarcoidosis, Multicentric Castleman's Disease (MCD), tocilizumab, IL-6

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 21 Pages 3061-3066

DOI https://doi.org/10.2169/internalmedicine.51.8120

Details

Abstract

Multicentric Castleman's Disease (MCD) is a systemic disease characterized by generalized lymphadenopathy and the proliferation of plasma cells. The development of MCD in a patient with preexisting sarcoidosis has not been previously reported. We herein describe a case of MCD developing in a 78-year-old woman with a 17-year history of sarcoidosis. The patient's serum interleukin-6 (IL-6) levels were only slightly elevated; however, the IL-6 levels in the fluid of both pleural effusion and ascites were markedly elevated. The administration of steroid-pulse therapy and prednisolone was ineffective in treating the MCD, although treatment with tocilizumab proved highly effective.

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