A Case of IgG4-related Sclerosing Cholangitis Overlapped with Primary Biliary Cirrhosis

Itaru Naitoh; Takahiro Nakazawa; Kazuki Hayashi; Katsuyuki Miyabe; Shuya Shimizu; Hiromu Kondo; Michihiro Yoshida; Hiroaki Yamashita; Shunsuke Nojiri; Satoru Takahashi; Takashi Joh

doi:10.2169/internalmedicine.51.7327

CASE REPORTS

A Case of IgG4-related Sclerosing Cholangitis Overlapped with Primary Biliary Cirrhosis

Itaru Naitoh, Takahiro Nakazawa, Kazuki Hayashi, Katsuyuki Miyabe, Shuya Shimizu, Hiromu Kondo, Michihiro Yoshida, Hiroaki Yamashita, Shunsuke Nojiri, Satoru Takahashi, Takashi Joh

Author information

Itaru Naitoh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Takahiro Nakazawa
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Kazuki Hayashi
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Katsuyuki Miyabe
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Shuya Shimizu
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hiromu Kondo
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Michihiro Yoshida
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Hiroaki Yamashita
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Shunsuke Nojiri
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
Satoru Takahashi
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, Japan
Takashi Joh
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan

Keywords: autoimmune pancreatitis, IgG4-related sclerosing cholangitis, primary biliary cirrhosis, steroid, ursodeoxycholic acid

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 13 Pages 1695-1699

DOI https://doi.org/10.2169/internalmedicine.51.7327

Details

Abstract

IgG4-related sclerosing cholangitis (IgG4-SC) and primary biliary cirrhosis (PBC) can both cause liver dysfunction. While IgG4-SC is associated with IgG4-related diseases such as autoimmune pancreatitis, PBC is associated with various autoimmune diseases. However, there is only one case report of an association between IgG4-SC and PBC, and this association has not been elucidated further. The treatments for these two diseases are different, i.e., corticosteroid treatment is performed for IgG4-SC and ursodeoxycholic acid is given for PBC. We report a case of IgG4-SC overlapping with PBC in a 45-year-old man who was successfully treated by combination therapy with prednisolone and ursodeoxycholic acid.

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