Occupational Liver Injury Due to N,N-Dimethylformamide in the Synthetics Industry

Maho Hamada; Masanori Abe; Yoshio Tokumoto; Teruki Miyake; Hidehiro Murakami; Yoichi Hiasa; Bunzo Matsuura; Kohei Sato; Morikazu Onji

doi:10.2169/internalmedicine.48.2332

CASE REPORTS

Occupational Liver Injury Due to N,N-Dimethylformamide in the Synthetics Industry

Maho Hamada, Masanori Abe, Yoshio Tokumoto, Teruki Miyake, Hidehiro Murakami, Yoichi Hiasa, Bunzo Matsuura, Kohei Sato, Morikazu Onji

Author information

Maho Hamada
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Masanori Abe
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Yoshio Tokumoto
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Teruki Miyake
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Hidehiro Murakami
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Yoichi Hiasa
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Bunzo Matsuura
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine
Kohei Sato
Department of Internal Medicine, Kyoritsu Hospital
Morikazu Onji
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine

Keywords: occupational liver injury, synthetics industry, N,N-dimethylformamide

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 18 Pages 1647-1650

DOI https://doi.org/10.2169/internalmedicine.48.2332

Details

Abstract

N,N-dimethylformamide (DMF) is a solvent used extensively in the chemical industry. The main toxic effect reported after exposure to DMF is hepatotoxicity. We encountered four patients with liver injury due to DMF exposure; the severity of the liver injury was related to the exposure levels. After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers.

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