Elevated Levels of Tenascin-C in Patients with Cryptogenic Organizing Pneumonia

Keiko Hisatomi; Noriho Sakamoto; Hiroshi Mukae; Tomayoshi Hayashi; Misato Amenomori; Hiroshi Ishimoto; Hanako Fujita; Hiroshi Ishii; Seiko Nakayama; Yuji Ishimatsu; Shigeru Kohno

doi:10.2169/internalmedicine.48.2233

ORIGINAL ARTICLES

Elevated Levels of Tenascin-C in Patients with Cryptogenic Organizing Pneumonia

Keiko Hisatomi, Noriho Sakamoto, Hiroshi Mukae, Tomayoshi Hayashi, Misato Amenomori, Hiroshi Ishimoto, Hanako Fujita, Hiroshi Ishii, Seiko Nakayama, Yuji Ishimatsu, Shigeru Kohno

Author information

Keiko Hisatomi
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Noriho Sakamoto
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hiroshi Mukae
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Tomayoshi Hayashi
Department of Pathology, Nagasaki University Hospital
Misato Amenomori
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hiroshi Ishimoto
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hanako Fujita
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Hiroshi Ishii
Department of Internal Medicine II, Oita University Faculty of Medicine
Seiko Nakayama
Department of General Medicine, Nagasaki University Hospital
Yuji Ishimatsu
The Second Department of Internal Medicine, Nagasaki University School of Medicine
Shigeru Kohno
The Second Department of Internal Medicine, Nagasaki University School of Medicine

Keywords: bronchial inflammation, diffuse parenchymal lung diseases, extracellular matrix, idiopathic interstitial pneumonias, idiopathic pulmonary fibrosis

JOURNAL OPEN ACCESS

2009 Volume 48 Issue 17 Pages 1501-1507

DOI https://doi.org/10.2169/internalmedicine.48.2233

Details

Abstract

Objective Idiopathic interstitial pneumonias (IIPs) comprises a group of diffuse parenchymal lung diseases of unknown etiology with varying degrees of inflammation and fibrosis including cryptogenic organizing pneumonia (COP), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Tenascin-C is an extracellular matrix molecule that is expressed during wound healing in various tissues. The present study was aimed to investigate the role of tenascin-C in the pathogenesis of IIPs.
Methods We used enzyme-linked immunosorbent assays to measure levels of tenascin-C in serum and bronchoalveolar lavage fluid (BALF) from 17 patients with IPF, 12 with NSIP, 15 with COP and from 23 healthy individuals.
Results Serum levels of tenascin-C were significantly elevated in patients with COP compared with those in all other participants, whereas those in patients with IPF and NSIP were not significantly elevated compared with healthy individuals. The levels of tenascin-C in BALF from patients with COP and NSIP were significantly higher than those of healthy individuals. In addition, serum tenascin-C was significantly correlated with levels of serum C-reactive protein, which is a serum acute phase protein.
Conclusion Systemic inflammation in the lung with IIPs might be associated with tenascin-C. These results suggest that tenascin-C is responsible for the pathogenesis of IIPs especially via inflammation, and that it might serve as a serum marker of COP.

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