Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate

Fumiko Tanaka; Atsushi Kawakami; Nozomi Iwanaga; Mami Tamai; Yasumori Izumi; Kouichiro Aratake; Kazuhiko Arima; Makoto Kamachi; Hideki Nakamura; Mingguo Huang; Hiroaki Ida; Tomoki Origuchi; Katsumi Eguchi

doi:10.2169/internalmedicine.45.1377

CASE REPORTS

Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate

Fumiko Tanaka, Atsushi Kawakami, Nozomi Iwanaga, Mami Tamai, Yasumori Izumi, Kouichiro Aratake, Kazuhiko Arima, Makoto Kamachi, Hideki Nakamura, Mingguo Huang, Hiroaki Ida, Tomoki Origuchi, Katsumi Eguchi

Author information

Fumiko Tanaka
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Atsushi Kawakami
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nozomi Iwanaga
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Mami Tamai
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Yasumori Izumi
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Kouichiro Aratake
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Kazuhiko Arima
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Makoto Kamachi
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Hideki Nakamura
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Mingguo Huang
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Hiroaki Ida
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Tomoki Origuchi
Nagasaki University of Health Sciences, Nagasaki University
Katsumi Eguchi
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University

Keywords: Takayasu arteritis, infliximab

JOURNAL OPEN ACCESS

2006 Volume 45 Issue 5 Pages 313-316

DOI https://doi.org/10.2169/internalmedicine.45.1377

Details

Abstract

We have experienced a Takayasu arteritis (TA) patient, successfully treated with infliximab, who did not respond well to conventional therapy with glucocosteroid and methotrexate. Takayasu arteritis had developed in a 24yearold woman (March 2003) who had been treated with glucocorticoid including methylprednisolone pulse therapy and methotrexate; however, she relapsed during the tapering of the dosage of oral prednisolone. Nineteen months after the first administration of glucocorticoid, 3 mg/kg of infliximab was introduced to the patient. The therapeutic efficacy of infliximab was markedly demonstrated; the patient's Creactive protein (CRP) value returned to almost normal range with subsequent tapering of the dosage of oral prednisolone in the absence of further relapse. This is the first case presentation of TA in Japan successfully treated with infliximab.

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