Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection

Kojiro MICHITAKA; Norio HORIIKE; Yan CHEN; Tran Nhu DUONG; Ichiro KONISHI; Toshie MASHIBA; Yoshio TOKUMOTO; Yoichi HIASA; Yasuhito TANAKA; Masashi MIZOKAMI; Morikazu ONJI

doi:10.2169/internalmedicine.43.696

Gastrointestinal Diseases

Gianotti-Crosti Syndrome Caused by Acute Hepatitis B Virus Genotype D Infection

Kojiro MICHITAKA, Norio HORIIKE, Yan CHEN, Tran Nhu DUONG, Ichiro KONISHI, Toshie MASHIBA, Yoshio TOKUMOTO, Yoichi HIASA, Yasuhito TANAKA, Masashi MIZOKAMI, Morikazu ONJI

Author information

Kojiro MICHITAKA
Endoscopy Center, Ehime University School of Medicine
Norio HORIIKE
Third Department of Internal Medicine, Ehime University School of Medicine
Yan CHEN
Third Department of Internal Medicine, Ehime University School of Medicine
Tran Nhu DUONG
Third Department of Internal Medicine, Ehime University School of Medicine
Ichiro KONISHI
Third Department of Internal Medicine, Ehime University School of Medicine
Toshie MASHIBA
Third Department of Internal Medicine, Ehime University School of Medicine
Yoshio TOKUMOTO
Third Department of Internal Medicine, Ehime University School of Medicine
Yoichi HIASA
Third Department of Internal Medicine, Ehime University School of Medicine
Yasuhito TANAKA
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences
Masashi MIZOKAMI
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences
Morikazu ONJI
Third Department of Internal Medicine, Ehime University School of Medicine

Keywords: Gianotti-Crosti syndrome, hepatitis B virus, genotype D

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 8 Pages 696-699

DOI https://doi.org/10.2169/internalmedicine.43.696

Details

Abstract

A 12-year-old girl with Gianotti-Crosti syndrome caused by hepatitis B virus (HBV) infection was admitted due to eruption on her extremities. Laboratory findings revealed elevation of transaminase, positivity for HB surface antigen (HBsAg), and an IgM type anti-HB core. The eruption and level of transaminase improved, and HBsAg became negative within 2 months of onset. Analysis of the virus revealed it to be genotype D with a genomic length of 3, 182 bases and the HBsAg serotype was ayw3, which is very rare in Japan. The possible relationship between Gianotti-Crosti syndrome and HBV genotype D infection is discussed.

Corresponding author

Register with J-STAGE for free!