Peripheral Primitive Neuroectodermal Tumor of the Chest Wall of a 69-year-old Man

Yoko TAKAGI-TAKAHASHI; Noriharu SHIJUBO; Gen YAMADA; Eri SAITOH; Kaku SAWADA; Tetsuro OHNISHI; Takayuki ITOH; Toyohiro SAIKAI; Tatsuru IKEDA; Sachiko KIMURA; Hiroki TAKAHASHI; Shosaku ABE

doi:10.2169/internalmedicine.43.578

Respiratory Diseases

Peripheral Primitive Neuroectodermal Tumor of the Chest Wall of a 69-year-old Man

Yoko TAKAGI-TAKAHASHI, Noriharu SHIJUBO, Gen YAMADA, Eri SAITOH, Kaku SAWADA, Tetsuro OHNISHI, Takayuki ITOH, Toyohiro SAIKAI, Tatsuru IKEDA, Sachiko KIMURA, Hiroki TAKAHASHI, Shosaku ABE

Author information

Yoko TAKAGI-TAKAHASHI
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Noriharu SHIJUBO
Department of Respiratory Medicine, Sapporo Hospital, Hokkaido Railway Company
Gen YAMADA
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Eri SAITOH
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Kaku SAWADA
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Tetsuro OHNISHI
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Takayuki ITOH
Department of Respiratory Medicine, Sapporo Hospital, Hokkaido Railway Company
Toyohiro SAIKAI
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Tatsuru IKEDA
Department of Pathology, Sapporo Medical University School of Medicine
Sachiko KIMURA
Department of Pathology, Sapporo Medical University School of Medicine
Hiroki TAKAHASHI
Third Department of Internal Medicine, Sapporo Medical University School of Medicine
Shosaku ABE
Third Department of Internal Medicine, Sapporo Medical University School of Medicine

Keywords: MIC2, neuron-specific enolase, pro-gastrin releasing peptide, Ewing’s sarcoma, EWS/FLI-1 chimeric mRNA, pPNET

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 7 Pages 578-581

DOI https://doi.org/10.2169/internalmedicine.43.578

Details

Abstract

We report a case of peripheral primitive neuroectodermal tumor (pPNET), which belongs to the pPNET/Ewing’s sarcoma family, arising in the chest wall of a 69-year-old man. He had high levels of serum neuron-specific enolase and pro-gastrin-releasing peptide, which are believed to be useful diagnostic blood markers for small cell lung carcinoma (SCLC). Microscopically, the tumor was composed of solid nests and sheets of monotous, primitive, small round cells with a few rosettes, making it difficult to distinguish from SCLC. Immunohistochemically, the tumor cells showed intense cell membranous immunoreactivity for MIC2 protein (CD99). EWS/FLI-1 chimeric mRNA that originated from the characteristic t(11;22)(q24;q12) chromosomal translocation was detected by RT-PCR and nucleotide sequence analysis. These results confirmed the diagnostic validity of the present tumor being a pPNET, thus raising the possibility that in the past, pPNETs which have arisen in the chest have been mistakenly diagnosed as SCLC.

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