Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Treatment of Lymphocytic Hypophysitis by High-Dose Methylprednisolone Pulse Therapy
Keiko YAMAGAMIKatsunobu YOSHIOKAHaruna SAKAIMariko FUKUMOTOTetsuya YAMAKITAMasayuki HOSOITomofusa ISHIIToshihiko SATOShiro TANAKASatoru FUJII
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2003 Volume 42 Issue 2 Pages 168-173

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Abstract

A 26-year-old woman 3 months post-partum was admitted to our hospital suffering from gross visual disturbance. Magnetic resonance imaging (MRI) revealed a pituitary mass, extending into the suprasellar cistern, with intense gadolinium enhancement. Lymphocytic hypophysitis (LHy) was suspected, and the patient received high dose methylprednisolone pulse therapy (HDMPT). Her visual disturbance was dramatically ameliorated on the first day following initiation of HDMPT, and MRI revealed marked mass reduction. Her pituitary function recovered 6 months after therapy. This case report suggests that HDMPT proved effective for mass reduction of severe LHy and could obviate the need for a useless surgery.
(Internal Medicine 42: 168-173, 2003)

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© The Japanese Society of Internal Medicine
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