Objective Most cerebrovascular disturbances in Behçet's syndrome are occlusive in nature, while hemorrhage is rare. In this paper, we report three cases of neuro-Behçet's syndrome presenting with intracerebral hemorrhaging, and discuss the possible causes as they relate to cyclosporine treatment.
Patients Three cases of neuro-Behçet's syndrome presented with intracranial hemorrhage. One patient had been taking cyclosporine, and the other two patients had never taking cyclosporine.
Results Together with previous reports, these cases suggest that there are two types of intracranial hemorrhage in neuro-Behçet's syndrome. One type occurs in the center of a lesion and during the acute phase of the disease, while the other occurs in the peripheral lesion and during the subacute phase.
Conclusions It appears that the intractanial hemorrhages in neuro-Behçet's symdrome can be divided into two groups. It is possible that the vascular pathologies caused by Behçet's symdrome and by cyclosporine conspire to induce CNS hemorrhaging in some cases.
(Internal Medicine 41: 692-695, 2002)