The Production of Colony-Stimulating Factors by Thyroid Carcinoma Is Associated with Marked Neutrophilia and Eosinophilia

Tetsuya NAKADA; Hiromitsu SATO; Fuyuhiko INOUE; Fumi MIZOROGI; Kazuo NAGAYAMA; Teruji TANAKA

doi:10.2169/internalmedicine.35.815

Tetsuya NAKADA, Hiromitsu SATO, Fuyuhiko INOUE, Fumi MIZOROGI, Kazuo NAGAYAMA, Teruji TANAKA

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Keywords: granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), CSF-producing carcinoma, granulocytosis

JOURNAL FREE ACCESS

1996 Volume 35 Issue 10 Pages 815-820

DOI https://doi.org/10.2169/internalmedicine.35.815

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Abstract

Cancers producing colony-stimulating factors and associated with marked leukocytosis are relatively rare. We report here a case of a thyroid cancer producing both granulocyte colonystimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF). A 72-year-old woman had a thyroid carcinoma with significant neutrophilia and eosinophilia without any evidence of infection. The serum concentrations of both G-CSF and GM-CSF were elevated significantly in this patient, which might have induced the leukocytosis. Furthermore, the G-CSF concentrations in thyroid tumor tissue and metastatic lesions in the lung and skin examined at autopsy also were extremely high.
(Internal Medicine 35: 815-820, 1996)

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